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Krohn2011 Cerebral Amyloid Proteostasis Regulated By Membrane Transp Lab

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Krohn2011 - Cerebral amyloid-βproteostasis regulated by membrane transport protein ABCC1 This model is described in the article: Cerebral amyloid-β proteostasis is regulated by the membrane transport. It can be used to explore systemsbiology krohn2011 cerebral amyloid proteostasis regulate dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
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Metadata

Packagekrohn2011-cerebral-amyloid-proteostasis-regulated-by-membrane-tr
Created2026-05-17
Updated2026-05-17
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_soluble_obs",
        "label": "Initial Soluble Obs",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.initial_soluble_obs",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `soluble_obs`."
      },
      {
        "name": "initial_insoluble_obs",
        "label": "Initial Insoluble Obs",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.initial_insoluble_obs",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `insoluble_obs`."
      },
      {
        "name": "initial_model_state_a9",
        "label": "Initial Model State A9",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.initial_model_state_a9",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `A9`."
      },
      {
        "name": "initial_model_state_a8",
        "label": "Initial Model State A8",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.initial_model_state_a8",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `A8`."
      },
      {
        "name": "initial_model_state_a7",
        "label": "Initial Model State A7",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.initial_model_state_a7",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `A7`."
      },
      {
        "name": "initial_model_state_a54",
        "label": "Initial Model State A54",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.initial_model_state_a54",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `A54`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.species_labels"
      },
      {
        "name": "soluble_obs",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.soluble_obs"
      },
      {
        "name": "insoluble_obs",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.insoluble_obs"
      },
      {
        "name": "model_state_a9",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.model_state_a9"
      },
      {
        "name": "model_state_a8",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.model_state_a8"
      },
      {
        "name": "model_state_a7",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.model_state_a7"
      },
      {
        "name": "a54",
        "maps_to": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.a54"
      }
    ]
  },
  "tags": [
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Krohn2011 Cerebral Amyloid Proteostasis Regulated By Membrane Transp Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model",
      "alias": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model_state"
      ],
      "from": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model_summary"
      ],
      "from": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model_species_labels"
      ],
      "from": "systemsbiology_sbml_krohn2011_cerebral_amyloid_proteostasis_regulate_biomd0000000618_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Krohn2011 - Cerebral amyloid-βproteostasis regulated by membrane transport protein ABCC1 This model is described in the article: Cerebral amyloid-β proteostasis is regulated by the membrane transport. It can be used to explore systemsbiology krohn2011 cerebral amyloid proteostasis regulate dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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