MODEL1704110003 Variant Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 Lab
About lab
Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 (MODEL1704110003)
This Biosimulant lab wraps MODEL1704110003 Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 as a runnable systems biology model with a companion visualization module.
Proctor2017 - Identifying microRNA for muscleregeneration during ageing (Mir143_in_muscle) This model is described in the article: Using computer simulation models to investigate the most promising mi. It can be used to explore the configured dynamics and compare scenario outcomes across configurations.
What You'll See
The lab asks: Which gene-regulatory states dominate the source model trajectory? Source model: Proctor2017 - Identifying microRNA for muscle regeneration during ageing (Mir143_in_muscle). It runs for 1.0 time units with a communication step of 0.1. The run uses the model defaults declared by the curated SBML wrapper. The generated visualizations focus on MyoD, Igf2, IL6, MiR143, Igfbp5, and Akt, combining trajectory, endpoint-comparison, and summary-table views from one completed dark-mode run.
In this captured run, IL6 moved from 500.0 to 499.3 across 1.0 simulation windows.
Output Visualizations

Summary table for Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3, reporting the scientific question, observed answer, dominant module, and caveat.

Trajectories of IL6, MiR143, Igfbp5, Igf2, MyoD, and Akt across the 1.0 simulation. In this run IL6 fell from 500.0 to 499.3 — the largest movements among the focused observables.

Largest-excursion ranking of the focused observables — the absolute movement magnitude during the run. Top 3: IL6 = 0.7262, MiR143 = 0.3572, Igfbp5 = 0.2277, with 3 more observables below.

Endpoint snapshot of the focused observables — final values from the captured run. Top 3 by value: MyoD = 500.0, Igf2 = 499.8, IL6 = 499.3, with 3 more observables below.

Visualization card from the Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 dark-mode run.
Model Context
- Core model:
models/core - Visualization model:
models/visualisation - Standard:
other - Upstream source:
biomodels_ebi:MODEL1704110003 - License:
CC0
Inputs
| Input | Maps To | Default | Notes |
|---|---|---|---|
| Initial Myo D | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_myo_d | Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol MyoD. | |
| Initial Igf2 | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_igf2 | Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Igf2. | |
| Initial Model State IL6 | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_model_state_il6 | Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol IL6. | |
| Initial Mi R143 | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_mi_r143 | Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol miR143. | |
| Initial Igfbp5 | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_igfbp5 | Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Igfbp5. | |
| Initial Model State Akt | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_model_state_akt | Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Akt. |
Outputs
| Output | Maps To | Role |
|---|---|---|
state | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.state | Available to the visualization model and downstream workflows. |
summary | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.summary | Available to the visualization model and downstream workflows. |
species_labels | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.species_labels | Available to the visualization model and downstream workflows. |
myo_d | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.myo_d | Available to the visualization model and downstream workflows. |
igf2 | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.igf2 | Available to the visualization model and downstream workflows. |
il6 | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.il6 | Available to the visualization model and downstream workflows. |
mi_r143 | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.mi_r143 | Available to the visualization model and downstream workflows. |
igfbp5 | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.igfbp5 | Available to the visualization model and downstream workflows. |
akt | systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.akt | Available to the visualization model and downstream workflows. |
Runtime
- Duration:
1.0 - Communication step:
0.1
Running Locally
biosimulant labs serve
Proctor2017 - Identifying microRNA for muscleregeneration during ageing (Mir143_in_muscle) This model is described in the article: Using computer simulation models to investigate the most promising mi. It can be used to explore systemsbiology proctor2017 identifying microrna for muscle dynamics and compare simulation behavior across conditions.
Runtime
Runs
Metadata
Manifest
{
"io": {
"inputs": [
{
"name": "initial_myo_d",
"label": "Initial Myo D",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_myo_d",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MyoD`."
},
{
"name": "initial_igf2",
"label": "Initial Igf2",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_igf2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Igf2`."
},
{
"name": "initial_model_state_il6",
"label": "Initial Model State IL6",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_model_state_il6",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IL6`."
},
{
"name": "initial_mi_r143",
"label": "Initial Mi R143",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_mi_r143",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `miR143`."
},
{
"name": "initial_igfbp5",
"label": "Initial Igfbp5",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_igfbp5",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Igfbp5`."
},
{
"name": "initial_model_state_akt",
"label": "Initial Model State Akt",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_model_state_akt",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Akt`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.species_labels"
},
{
"name": "myo_d",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.myo_d"
},
{
"name": "igf2",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.igf2"
},
{
"name": "il6",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.il6"
},
{
"name": "mi_r143",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.mi_r143"
},
{
"name": "igfbp5",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.igfbp5"
},
{
"name": "akt",
"maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.akt"
}
]
},
"tags": [
"generegulation",
"physiology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "MODEL1704110003 Variant Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 Lab",
"models": [
{
"path": "owned/models/systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model",
"alias": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model",
"provenance": {
"owned_path": "owned/models/systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model_state"
],
"from": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model_summary"
],
"from": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model_species_labels"
],
"from": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.species_labels"
}
],
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"description": "Proctor2017 - Identifying microRNA for muscleregeneration during ageing (Mir143_in_muscle) This model is described in the article: Using computer simulation models to investigate the most promising mi. It can be used to explore systemsbiology proctor2017 identifying microrna for muscle dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
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