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MODEL1704110003 Variant Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 Lab

About lab

Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 (MODEL1704110003)

This Biosimulant lab wraps MODEL1704110003 Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 as a runnable systems biology model with a companion visualization module. Proctor2017 - Identifying microRNA for muscleregeneration during ageing (Mir143_in_muscle) This model is described in the article: Using computer simulation models to investigate the most promising mi. It can be used to explore the configured dynamics and compare scenario outcomes across configurations.

What You'll See

The lab asks: Which gene-regulatory states dominate the source model trajectory? Source model: Proctor2017 - Identifying microRNA for muscle regeneration during ageing (Mir143_in_muscle). It runs for 1.0 time units with a communication step of 0.1. The run uses the model defaults declared by the curated SBML wrapper. The generated visualizations focus on MyoD, Igf2, IL6, MiR143, Igfbp5, and Akt, combining trajectory, endpoint-comparison, and summary-table views from one completed dark-mode run.

In this captured run, IL6 moved from 500.0 to 499.3 across 1.0 simulation windows.

Output Visualizations

Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 - run interpretation

Summary table for Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3, reporting the scientific question, observed answer, dominant module, and caveat.

Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 - timeseries visualization

Trajectories of IL6, MiR143, Igfbp5, Igf2, MyoD, and Akt across the 1.0 simulation. In this run IL6 fell from 500.0 to 499.3 — the largest movements among the focused observables.

Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 - excursions bar

Largest-excursion ranking of the focused observables — the absolute movement magnitude during the run. Top 3: IL6 = 0.7262, MiR143 = 0.3572, Igfbp5 = 0.2277, with 3 more observables below.

Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 - endpoint snapshot bar

Endpoint snapshot of the focused observables — final values from the captured run. Top 3 by value: MyoD = 500.0, Igf2 = 499.8, IL6 = 499.3, with 3 more observables below.

Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 - visualization

Visualization card from the Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 dark-mode run.

Model Context

  • Core model: models/core
  • Visualization model: models/visualisation
  • Standard: other
  • Upstream source: biomodels_ebi:MODEL1704110003
  • License: CC0

Inputs

InputMaps ToDefaultNotes
Initial Myo Dsystemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_myo_dSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol MyoD.
Initial Igf2systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_igf2Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Igf2.
Initial Model State IL6systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_model_state_il6Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol IL6.
Initial Mi R143systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_mi_r143Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol miR143.
Initial Igfbp5systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_igfbp5Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Igfbp5.
Initial Model State Aktsystemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_model_state_aktSource state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol Akt.

Outputs

OutputMaps ToRole
statesystemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.stateAvailable to the visualization model and downstream workflows.
summarysystemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.summaryAvailable to the visualization model and downstream workflows.
species_labelssystemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.species_labelsAvailable to the visualization model and downstream workflows.
myo_dsystemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.myo_dAvailable to the visualization model and downstream workflows.
igf2systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.igf2Available to the visualization model and downstream workflows.
il6systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.il6Available to the visualization model and downstream workflows.
mi_r143systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.mi_r143Available to the visualization model and downstream workflows.
igfbp5systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.igfbp5Available to the visualization model and downstream workflows.
aktsystemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.aktAvailable to the visualization model and downstream workflows.

Runtime

  • Duration: 1.0
  • Communication step: 0.1

Running Locally

biosimulant labs serve

Proctor2017 - Identifying microRNA for muscleregeneration during ageing (Mir143_in_muscle) This model is described in the article: Using computer simulation models to investigate the most promising mi. It can be used to explore systemsbiology proctor2017 identifying microrna for muscle dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagemodel1704110003-proctor2017-identifying-microrna-for-muscle-rege
Created2026-05-17
Updated2026-05-17
generegulationphysiologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_myo_d",
        "label": "Initial Myo D",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_myo_d",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MyoD`."
      },
      {
        "name": "initial_igf2",
        "label": "Initial Igf2",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_igf2",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Igf2`."
      },
      {
        "name": "initial_model_state_il6",
        "label": "Initial Model State IL6",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_model_state_il6",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IL6`."
      },
      {
        "name": "initial_mi_r143",
        "label": "Initial Mi R143",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_mi_r143",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `miR143`."
      },
      {
        "name": "initial_igfbp5",
        "label": "Initial Igfbp5",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_igfbp5",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Igfbp5`."
      },
      {
        "name": "initial_model_state_akt",
        "label": "Initial Model State Akt",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.initial_model_state_akt",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Akt`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.species_labels"
      },
      {
        "name": "myo_d",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.myo_d"
      },
      {
        "name": "igf2",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.igf2"
      },
      {
        "name": "il6",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.il6"
      },
      {
        "name": "mi_r143",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.mi_r143"
      },
      {
        "name": "igfbp5",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.igfbp5"
      },
      {
        "name": "akt",
        "maps_to": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.akt"
      }
    ]
  },
  "tags": [
    "generegulation",
    "physiology",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "MODEL1704110003 Variant Proctor2017 Identifying Microrna For Muscle Regeneration During Ageing 3 Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model",
      "alias": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model_state"
      ],
      "from": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model_summary"
      ],
      "from": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model_species_labels"
      ],
      "from": "systemsbiology_sbml_proctor2017_identifying_microrna_for_muscle_rege_model1704110003_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Proctor2017 - Identifying microRNA for muscleregeneration during ageing (Mir143_in_muscle) This model is described in the article: Using computer simulation models to investigate the most promising mi. It can be used to explore systemsbiology proctor2017 identifying microrna for muscle dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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