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Leber2016 - Regulatory macrophage differentiation - H.pylori infection Lab

About lab

The model is the second model of the publication 'Modeling the role of lanthionine synthetase C-like 2 (LANCL2) in the modulation of immune responses to Helicobacter pylori infection' published in Plo. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packageleber2016-regulatory-macrophage-differentiation-h-pylori-infecti
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_cx3cr1_receptor",
        "label": "Initial Cx3cr1 Receptor",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.initial_cx3cr1_receptor",
        "description": "Initial Cx3cr1 Receptor. Sets the initial value of bundled SBML species `s1`."
      },
      {
        "name": "initial_unresolved_infection_observable_1",
        "label": "Initial Unresolved Infection Observable 1",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.initial_unresolved_infection_observable_1",
        "description": "Initial Unresolved Infection Observable 1. Sets the initial value of bundled SBML species `s2`."
      },
      {
        "name": "initial_erk",
        "label": "Initial ERK",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.initial_erk",
        "description": "Initial ERK. Sets the initial value of bundled SBML species `s3`."
      },
      {
        "name": "initial_unresolved_infection_observable_2",
        "label": "Initial Unresolved Infection Observable 2",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.initial_unresolved_infection_observable_2",
        "description": "Initial Unresolved Infection Observable 2. Sets the initial value of bundled SBML species `s4`."
      }
    ],
    "outputs": [
      {
        "name": "cx3cr1_receptor",
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.cx3cr1_receptor"
      },
      {
        "name": "unresolved_infection_observable_1",
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.unresolved_infection_observable_1"
      },
      {
        "name": "erk",
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.erk"
      },
      {
        "name": "unresolved_infection_observable_2",
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.unresolved_infection_observable_2"
      },
      {
        "name": "unresolved_infection_observable_3",
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.unresolved_infection_observable_3"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.species_labels"
      }
    ]
  },
  "title": "Leber2016 - Regulatory macrophage differentiation - H.pylori infection Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model",
      "alias": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model_state"
      ],
      "from": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model_summary"
      ],
      "from": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model_species_labels"
      ],
      "from": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "The model is the second model of the publication 'Modeling the role of lanthionine synthetase C-like 2 (LANCL2) in the modulation of immune responses to Helicobacter pylori infection' published in Plo. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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