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Physiome 4fb - Feedback Control T Cell Receptor Activation Lab

About lab

Source-faithful physiology lab for Feedback control of T-cell receptor activation. Public controls and outputs are mapped to real source symbols for signalling physiology.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

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Completed0
Failed0

Metadata

Packagephysiome-4fb-feedback-control-t-cell-receptor-activation-lab
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_lck_active",
        "label": "Initial Lck Active",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.initial_lck_active",
        "description": "Initial value for Lck Active. Maps to source symbol `lck_active`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "micromolar"
        ]
      },
      {
        "name": "initial_lck_inactive",
        "label": "Initial Lck Inactive",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.initial_lck_inactive",
        "description": "Initial value for Lck Inactive. Maps to source symbol `lck_inactive`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "micromolar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.variable_labels"
      },
      {
        "name": "lck_active",
        "label": "Lck Active",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.lck_active",
        "description": "Lck Active. Maps to source symbol `lck_active`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "lck_inactive",
        "label": "Lck Inactive",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.lck_inactive",
        "description": "Lck Inactive. Maps to source symbol `lck_inactive`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "phosphatase_active",
        "label": "Phosphatase Active",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.phosphatase_active",
        "description": "Phosphatase Active. Maps to source symbol `phosphatase_active`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "phosphatase_inactive",
        "label": "Phosphatase Inactive",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.phosphatase_inactive",
        "description": "Phosphatase Inactive. Maps to source symbol `phosphatase_inactive`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "lck_total",
        "label": "Lck Total",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.lck_total",
        "description": "Lck Total. Maps to source symbol `lck_total`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "rate_constant_r_l",
        "label": "Rate Constant R L (source r_l)",
        "maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.rate_constant_r_l",
        "description": "Rate Constant R L (source r_l). Maps to source symbol `r_l`. Units: micromolar_per_second. Naming evidence: units identify a rate constant but not a fuller biological role."
      }
    ]
  },
  "title": "Physiome 4fb - Feedback Control T Cell Receptor Activation Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model",
      "alias": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model",
      "parameters": {
        "model_path": "data/chan_SHP12004.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model_state"
      ],
      "from": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model_summary"
      ],
      "from": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model_trajectory"
      ],
      "from": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model_variable_labels"
      ],
      "from": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Feedback control of T-cell receptor activation. Public controls and outputs are mapped to real source symbols for signalling physiology.",
  "schema_version": "2.0"
}

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