Fujita2010 - Decoupling Receptor Downstream Signals Akt Pathway By Its Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_akt",
        "label": "Initial Akt",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.initial_akt",
        "description": "Initial value for Akt. Maps to source symbol `Akt`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "dimensionless"
        ]
      },
      {
        "name": "initial_egf_egfr",
        "label": "Initial Egf Egfr",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.initial_egf_egfr",
        "description": "Initial value for Egf Egfr. Maps to source symbol `EGF_EGFR`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "dimensionless"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.variable_labels"
      },
      {
        "name": "akt",
        "label": "Akt",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.akt",
        "description": "Akt. Maps to source symbol `Akt`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "egf_egfr",
        "label": "Egf Egfr",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.egf_egfr",
        "description": "Egf Egfr. Maps to source symbol `EGF_EGFR`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "egf_egfr_i",
        "label": "Egf Egfr I",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.egf_egfr_i",
        "description": "Egf Egfr I. Maps to source symbol `EGF_EGFR_i`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "egfr",
        "label": "Egfr",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.egfr",
        "description": "Egfr. Maps to source symbol `EGFR`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "model_state_p_s6",
        "label": "Model State P S6 (source pS6)",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.model_state_p_s6",
        "description": "Model State P S6 (source pS6). Maps to source symbol `pS6`. Units: dimensionless. Naming evidence: source symbol is dimensionless but lacks enough evidence for a biological label."
      },
      {
        "name": "s6_signaling_activity",
        "label": "S6 Signaling Activity (source S6)",
        "maps_to": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.s6_signaling_activity",
        "description": "S6 Signaling Activity (source S6). Maps to source symbol `S6`. Units: dimensionless. Naming evidence: AKT/signalling context supports a conservative S6 activity label."
      }
    ]
  },
  "title": "Fujita2010 - Decoupling Receptor Downstream Signals Akt Pathway By Its Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model",
      "parameters": {
        "model_path": "data/fujita_2010_EGFR_inhibited_Akt.cellml",
        "integration_step": 0.01
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model_state"
      ],
      "from": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model_summary"
      ],
      "from": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model_trajectory"
      ],
      "from": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model_variable_labels"
      ],
      "from": "physiology_cellml_fujita_toyoshima_uda_ozaki_kubota_and_kuroda_201_fujitatoyoshimaudaozakikubotakuroda2010_model.variable_labels"
    }
  ],
  "package": "fujita2010-decoupling-receptor-downstream-signals-akt-p-c7054362",
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "version": "1.0.0",
  "description": "Source-faithful physiology lab for Fujita, Toyoshima, Uda, Ozaki, Kubota and Kuroda 2010. Public controls and outputs are mapped to real source symbols for signalling physiology.",
  "schema_version": "2.0"
}