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Nikolaev2019 - Immunobiochemical reconstruction of influenza lung infection-melanoma skin cancer interactions Lab

About lab

This is a mathematical mechanistic immunobiochemical model that incorporates T cell pathways that control programmed cell death protein 1 (PD-1) expression. A core component of the model is a kinetic.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagenikolaev2019-immunobiochemical-reconstruction-of-influenza-lung
Created2026-05-16
Updated2026-05-16
biomodels_ebicuratedfaithfulimmunologyimmunotherapymicroenvironmentoncologyphysiologysbmlsystemsbiologytumor-growthvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "sigma_p_tilde_source_parameter",
        "label": "Sigma p tilde source parameter",
        "units": "native SBML value",
        "default": 0.1,
        "maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.sigma_p_tilde_source_parameter",
        "description": "Sigma p tilde source parameter. Maps to bundled SBML parameter `sigma_p_tilde`."
      }
    ],
    "outputs": [
      {
        "name": "chemotherapy_level",
        "maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.chemotherapy_level",
        "description": "C observable. Maps to SBML symbol `C`."
      },
      {
        "name": "p",
        "maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.p",
        "description": "P observable. Maps to SBML symbol `P`."
      },
      {
        "name": "infected_tumor_cells",
        "maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.infected_tumor_cells",
        "description": "I observable. Maps to SBML symbol `I`."
      },
      {
        "name": "b",
        "maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.b",
        "description": "B observable. Maps to SBML symbol `B`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "faithful",
    "immunology",
    "immunotherapy",
    "microenvironment",
    "oncology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Nikolaev2019 - Immunobiochemical reconstruction of influenza lung infection-melanoma skin cancer interactions Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model",
      "alias": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model_state"
      ],
      "from": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model_summary"
      ],
      "from": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model_species_labels"
      ],
      "from": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This is a mathematical mechanistic immunobiochemical model that incorporates T cell pathways that control programmed cell death protein 1 (PD-1) expression. A core component of the model is a kinetic.",
  "schema_version": "2.0"
}

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