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Qosa2014 - Mechanistic modeling that describes amyloid-Beta clearance across BBB Lab

About lab

Qosa2014 - Mechanistic modeling thatdescribes Aβ clearance across BBB Qosa2014 - Mechanistic modeling thatdescribes Aβ clearance across BBB. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.

Runtime

Duration24
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packageqosa2014-mechanistic-modeling-that-describes-amyloid-beta-cleara
Created2026-05-16
Updated2026-05-16
pharmacologyneurosciencepbpkphysiologyblood-brain-barriersbmltelluriumfaithfulbiomodels_ebivisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_cellular_amyloid_beta_hcmec_d3",
        "label": "Initial Cellular Amyloid Beta Hcmec D3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.initial_cellular_amyloid_beta_hcmec_d3"
      },
      {
        "name": "initial_cellular_amyloid_beta_bend3",
        "label": "Initial Cellular Amyloid Beta Bend3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.initial_cellular_amyloid_beta_bend3"
      },
      {
        "name": "initial_media_amyloid_beta_hcmec_d3",
        "label": "Initial Media Amyloid Beta Hcmec D3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.initial_media_amyloid_beta_hcmec_d3"
      },
      {
        "name": "initial_media_amyloid_beta_bend3",
        "label": "Initial Media Amyloid Beta Bend3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.initial_media_amyloid_beta_bend3"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.state"
      },
      {
        "name": "summary",
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        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.summary"
      },
      {
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        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.species_labels"
      },
      {
        "name": "intact_amyloid_beta_hcmec_d3",
        "label": "Intact Amyloid Beta Hcmec D3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.intact_amyloid_beta_hcmec_d3"
      },
      {
        "name": "intact_amyloid_beta_bend3",
        "label": "Intact Amyloid Beta Bend3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.intact_amyloid_beta_bend3"
      },
      {
        "name": "cellular_amyloid_beta_hcmec_d3",
        "label": "Cellular Amyloid Beta Hcmec D3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.cellular_amyloid_beta_hcmec_d3"
      },
      {
        "name": "degraded_amyloid_beta_hcmec_d3",
        "label": "Degraded Amyloid Beta Hcmec D3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.degraded_amyloid_beta_hcmec_d3"
      },
      {
        "name": "cellular_amyloid_beta_bend3",
        "label": "Cellular Amyloid Beta Bend3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.cellular_amyloid_beta_bend3"
      },
      {
        "name": "degraded_amyloid_beta_bend3",
        "label": "Degraded Amyloid Beta Bend3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.degraded_amyloid_beta_bend3"
      },
      {
        "name": "media_amyloid_beta_hcmec_d3",
        "label": "Media Amyloid Beta Hcmec D3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.media_amyloid_beta_hcmec_d3"
      },
      {
        "name": "media_amyloid_beta_bend3",
        "label": "Media Amyloid Beta Bend3",
        "maps_to": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model.media_amyloid_beta_bend3"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "neuroscience",
    "pbpk",
    "physiology",
    "blood-brain-barrier",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Qosa2014 - Mechanistic modeling that describes amyloid-Beta clearance across BBB Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model",
      "alias": "pharmacology_sbml_qosa2014_mechanistic_modeling_that_describes_amy_model1409240002_model",
      "parameters": {
        "model_path": "data/MODEL1409240002.xml",
        "integration_step": 0.1
      },
      "provenance": {
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      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
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  ],
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    },
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      ],
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    }
  ],
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Qosa2014 - Mechanistic modeling thatdescribes Aβ clearance across BBB Qosa2014 - Mechanistic modeling thatdescribes Aβ clearance across BBB. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}

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