Rodrigues2019 - A mathematical model for chemoimmunotherapy of chronic lymphocytic leukemia Lab

{
  "io": {
    "inputs": [
      {
        "name": "chemotherapy_input_source_parameter",
        "label": "Chemotherapy Input source parameter",
        "units": "native SBML value",
        "default": 8640,
        "maps_to": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.chemotherapy_input_source_parameter",
        "description": "Chemotherapy Input source parameter. Maps to bundled SBML parameter `Chemotherapy_Input`."
      },
      {
        "name": "immunotherapy_input_source_parameter",
        "label": "Immunotherapy Input source parameter",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.immunotherapy_input_source_parameter",
        "description": "Immunotherapy Input source parameter. Maps to bundled SBML parameter `Immunotherapy_Input`."
      },
      {
        "name": "infusion_dose_source_parameter",
        "label": "Infusion Dose source parameter",
        "units": "native SBML value",
        "default": 1080,
        "maps_to": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.infusion_dose_source_parameter",
        "description": "Infusion Dose source parameter. Maps to bundled SBML parameter `Infusion_Dose`."
      }
    ],
    "outputs": [
      {
        "name": "normal_cells",
        "maps_to": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.normal_cells",
        "description": "N observable. Maps to SBML symbol `N`."
      },
      {
        "name": "infected_tumor_cells",
        "maps_to": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.infected_tumor_cells",
        "description": "I observable. Maps to SBML symbol `I`."
      },
      {
        "name": "q",
        "maps_to": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.q",
        "description": "Q observable. Maps to SBML symbol `Q`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "chemotherapy",
    "curated",
    "drug-response",
    "faithful",
    "immunology",
    "immunotherapy",
    "microenvironment",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Rodrigues2019 - A mathematical model for chemoimmunotherapy of chronic lymphocytic leukemia Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model",
      "alias": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model_state"
      ],
      "from": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model_summary"
      ],
      "from": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model_species_labels"
      ],
      "from": "oncology_sbml_rodrigues2019_a_mathematical_model_for_chemoimmu_biomd0000000879_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "THis is a simple ordinary differential equation model describing chemoimmunotherapy of chronic lymphocytic leukemia, including descriptions of the combinatorial effects of chemotherapy and adoptive ce. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}