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Trisilowati2018 - Optimal control of tumor-immune system interaction with treatment Lab

About lab

This is a mathematical model of a growing tumor and its interaction with the immune system. The model consists of four populations: tumor cells, dendritic cells (representing the innate immune system).

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagetrisilowati2018-optimal-control-of-tumor-immune-system-interacti
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_unresolved_tumor_observable_1",
        "label": "Initial Unresolved Tumor Observable 1",
        "units": "native source value",
        "default": 1000000,
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.initial_unresolved_tumor_observable_1",
        "description": "Initial Unresolved Tumor Observable 1. Sets the initial value of bundled SBML species `T_Tumor_Cells`."
      },
      {
        "name": "initial_cd8_t_cells",
        "label": "Initial CD8 T Cells",
        "units": "native source value",
        "default": 10,
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.initial_cd8_t_cells",
        "description": "Initial CD8 T Cells. Sets the initial value of bundled SBML species `L_CD8_T_Cells`."
      },
      {
        "name": "initial_cd4_t_cells",
        "label": "Initial CD4 T Cells",
        "units": "native source value",
        "default": 5,
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.initial_cd4_t_cells",
        "description": "Initial CD4 T Cells. Sets the initial value of bundled SBML species `H_CD4_T_Cells`."
      },
      {
        "name": "initial_dendritic_cells",
        "label": "Initial Dendritic Cells",
        "units": "native source value",
        "default": 10,
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.initial_dendritic_cells",
        "description": "Initial Dendritic Cells. Sets the initial value of bundled SBML species `D_Dendritic_Cells`."
      },
      {
        "name": "tumor_death_cd8_rate",
        "label": "Tumor Death CD8 Rate",
        "units": "native source value",
        "default": 4.2e-8,
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.tumor_death_cd8_rate",
        "description": "Tumor Death CD8 Rate. Sets bundled SBML parameter `alpha_1`."
      }
    ],
    "outputs": [
      {
        "name": "unresolved_tumor_observable_1",
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.unresolved_tumor_observable_1"
      },
      {
        "name": "cd8_t_cells",
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.cd8_t_cells"
      },
      {
        "name": "cd4_t_cells",
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.cd4_t_cells"
      },
      {
        "name": "dendritic_cells",
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.dendritic_cells"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.species_labels"
      }
    ]
  },
  "title": "Trisilowati2018 - Optimal control of tumor-immune system interaction with treatment Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model",
      "alias": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model_state"
      ],
      "from": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model_summary"
      ],
      "from": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model_species_labels"
      ],
      "from": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This is a mathematical model of a growing tumor and its interaction with the immune system. The model consists of four populations: tumor cells, dendritic cells (representing the innate immune system).",
  "schema_version": "2.0"
}

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