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Jarrett2015 - Modelling the interaction between immune response, bacterial dynamics and inflammatory damage Lab

About lab

Mathematical model of pro- and anti-inflammatory response, inflammation/damage and infection dynamics in BALB/c mouse with Staphylococcal aureus infection. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagejarrett2015-modelling-the-interaction-between-immune-response-ba
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_bacterial_infection_b",
        "label": "Initial Bacterial Infection B",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.initial_bacterial_infection_b",
        "description": "Initial Bacterial Infection B. Sets the initial value of bundled SBML species `bacterial_infection__B`."
      },
      {
        "name": "initial_anti_inflammatory_a",
        "label": "Initial Anti Inflammatory A",
        "units": "native source value",
        "default": 3,
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.initial_anti_inflammatory_a",
        "description": "Initial Anti Inflammatory A. Sets the initial value of bundled SBML species `anti_inflammatory__A`."
      },
      {
        "name": "initial_inflammation_i",
        "label": "Initial Inflammation I",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.initial_inflammation_i",
        "description": "Initial Inflammation I. Sets the initial value of bundled SBML species `inflammation__I`."
      },
      {
        "name": "initial_pro_inflammatory_p",
        "label": "Initial Pro Inflammatory P",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.initial_pro_inflammatory_p",
        "description": "Initial Pro Inflammatory P. Sets the initial value of bundled SBML species `pro_inflammatory__P`."
      }
    ],
    "outputs": [
      {
        "name": "bacterial_infection_b",
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.bacterial_infection_b"
      },
      {
        "name": "anti_inflammatory_a",
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.anti_inflammatory_a"
      },
      {
        "name": "inflammation_i",
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.inflammation_i"
      },
      {
        "name": "pro_inflammatory_p",
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.pro_inflammatory_p"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.species_labels"
      }
    ]
  },
  "title": "Jarrett2015 - Modelling the interaction between immune response, bacterial dynamics and inflammatory damage Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model",
      "alias": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model_state"
      ],
      "from": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model_summary"
      ],
      "from": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model_species_labels"
      ],
      "from": "immunology_sbml_jarrett2015_modelling_the_interaction_between_im_biomd0000000920_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Mathematical model of pro- and anti-inflammatory response, inflammation/damage and infection dynamics in BALB/c mouse with Staphylococcal aureus infection. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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