Hoffmann2002_WT_IkBNFkB_Signaling Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_inhibitor_kappa_b_alpha",
        "label": "Initial inhibitor kappa B alpha",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.initial_inhibitor_kappa_b_alpha",
        "description": "Initial inhibitor kappa B alpha level. Maps to SBML symbol `IkBalpha`; exposed as a traceable initial-condition perturbation."
      },
      {
        "name": "initial_ik_balpha",
        "label": "Initial inhibitor kappa B alpha (legacy)",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.initial_ik_balpha",
        "description": "Legacy alias for initial inhibitor kappa B alpha. Maps to SBML symbol `IkBalpha`; exposed as a traceable initial-condition perturbation."
      }
    ],
    "outputs": [
      {
        "name": "nuclear_factor_kappa_b",
        "label": "Nuclear factor kappa B",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.nuclear_factor_kappa_b",
        "description": "Nuclear factor kappa B. Maps to SBML symbol `NFkB` and is emitted in native SBML units."
      },
      {
        "name": "inhibitor_kappa_b_alpha_nuclear_factor_kappa_b_complex",
        "label": "Inhibitor kappa B alpha - nuclear factor kappa B complex",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.inhibitor_kappa_b_alpha_nuclear_factor_kappa_b_complex",
        "description": "Inhibitor kappa B alpha bound to nuclear factor kappa B. Maps to SBML symbol `IkBalpha_NFkB` and is emitted in native SBML units."
      },
      {
        "name": "inhibitor_kappa_b_beta_nuclear_factor_kappa_b_complex",
        "label": "Inhibitor kappa B beta - nuclear factor kappa B complex",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.inhibitor_kappa_b_beta_nuclear_factor_kappa_b_complex",
        "description": "Inhibitor kappa B beta bound to nuclear factor kappa B. Maps to SBML symbol `IkBbeta_NFkB` and is emitted in native SBML units."
      },
      {
        "name": "nfkb",
        "label": "NF-kB (legacy)",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.nfkb",
        "description": "Legacy alias for nuclear factor kappa B. Maps to SBML symbol `NFkB` and is emitted in native SBML units."
      },
      {
        "name": "ik_balpha_nf_k_b",
        "label": "Ik Balpha NF K B",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.ik_balpha_nf_k_b",
        "description": "Ik Balpha NF K B. Maps to SBML symbol `IkBalpha_NFkB` and is emitted in native SBML units."
      },
      {
        "name": "ik_bbeta_nf_k_b",
        "label": "Ik Bbeta NF K B",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.ik_bbeta_nf_k_b",
        "description": "Ik Bbeta NF K B. Maps to SBML symbol `IkBbeta_NFkB` and is emitted in native SBML units."
      },
      {
        "name": "state",
        "label": "Observable state",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.species_labels"
      }
    ]
  },
  "tags": [
    "signaling",
    "systems",
    "systems-biology",
    "sbml",
    "faithful",
    "biomodels_ebi",
    "nfkb"
  ],
  "title": "Hoffmann2002_WT_IkBNFkB_Signaling Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model_state"
      ],
      "from": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.state"
    },
    {
      "to": [
        "visualisation.signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model_summary"
      ],
      "from": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.summary"
    },
    {
      "to": [
        "visualisation.signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model_species_labels"
      ],
      "from": "signaling_sbml_hoffmann2002_wt_ikbnfkb_signaling_biomd0000000140_model.species_labels"
    }
  ],
  "package": "hoffmann2002-wt-ikbnfkb-signaling",
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "version": "1.0.0",
  "description": "Clean Biosimulant lab for NF-kB pathway signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
  "schema_version": "2.0"
}