Mager2005 - Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_free_drug_concentration",
        "label": "Initial Free Drug Concentration",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.initial_free_drug_concentration"
      },
      {
        "name": "initial_free_target_concentration",
        "label": "Initial Free Target Concentration",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.initial_free_target_concentration"
      },
      {
        "name": "target_binding_affinity_kd",
        "label": "Target Binding Affinity Kd",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.target_binding_affinity_kd"
      },
      {
        "name": "drug_elimination_rate",
        "label": "Drug Elimination Rate",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.drug_elimination_rate"
      },
      {
        "name": "complex_internalization_rate",
        "label": "Complex Internalization Rate",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.complex_internalization_rate"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.species_labels"
      },
      {
        "name": "free_drug_concentration",
        "label": "Free Drug Concentration",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.free_drug_concentration"
      },
      {
        "name": "total_target_amount",
        "label": "Total Target Amount",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.total_target_amount"
      },
      {
        "name": "free_target_concentration",
        "label": "Free Target Concentration",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.free_target_concentration"
      },
      {
        "name": "drug_target_complex",
        "label": "Drug Target Complex",
        "maps_to": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.drug_target_complex"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pharmacokinetics",
    "tmdd",
    "receptor-binding",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Mager2005 - Quasi-equilibrium pharmacokinetic model for drugs exhibiting target-mediated drug disposition Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model",
      "parameters": {
        "model_path": "data/BIOMD0000000765.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model_state"
      ],
      "from": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model_summary"
      ],
      "from": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model_species_labels"
      ],
      "from": "pharmacology_sbml_mager2005_quasi_equilibrium_pharmacokinetic_mode_biomd0000000765_model.species_labels"
    }
  ],
  "package": "mager2005-tmdd-quasi-equilibrium",
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This model was developed with the aim of constructing an equilibrium model of the pharmacokinetic behaviour of a drug exhibiting target-mediated drug disposition (TMDD). It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}