Heldt2018 Proliferation Quiescence Decision In Response To Dna Damag Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_cyclin_a_cdk2_total",
        "label": "Initial Cyclin A Cdk2 Total",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.initial_cyclin_a_cdk2_total",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `tCa`."
      },
      {
        "name": "initial_retinoblastoma_protein_total",
        "label": "Initial Retinoblastoma Protein Total",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.initial_retinoblastoma_protein_total",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `tRb`."
      },
      {
        "name": "initial_retinoblastoma_protein_hyperphosphorylated",
        "label": "Initial Retinoblastoma Protein Hyperphosphorylated",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.initial_retinoblastoma_protein_hyperphosphorylated",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `pRb`."
      },
      {
        "name": "initial_cyclin_a_cdk2",
        "label": "Initial Cyclin A Cdk2",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.initial_cyclin_a_cdk2",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Ca`."
      },
      {
        "name": "initial_cyclin_e_cdk2_total",
        "label": "Initial Cyclin E Cdk2 Total",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.initial_cyclin_e_cdk2_total",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `tCe`."
      },
      {
        "name": "initial_cyclin_e_cdk2_active",
        "label": "Initial Cyclin E Cdk2 Active",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.initial_cyclin_e_cdk2_active",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Ce`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.species_labels"
      },
      {
        "name": "cyclin_a_cdk2_total",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.cyclin_a_cdk2_total"
      },
      {
        "name": "retinoblastoma_protein_total",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.retinoblastoma_protein_total"
      },
      {
        "name": "retinoblastoma_protein_hyperphosphorylated",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.retinoblastoma_protein_hyperphosphorylated"
      },
      {
        "name": "cyclin_a_cdk2",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.cyclin_a_cdk2"
      },
      {
        "name": "cyclin_e_cdk2_total",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.cyclin_e_cdk2_total"
      },
      {
        "name": "cyclin_e_cdk2_active",
        "maps_to": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.cyclin_e_cdk2_active"
      }
    ]
  },
  "tags": [
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Heldt2018 Proliferation Quiescence Decision In Response To Dna Damag Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model",
      "alias": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model_state"
      ],
      "from": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model_summary"
      ],
      "from": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model_species_labels"
      ],
      "from": "systemsbiology_sbml_heldt2018_proliferation_quiescence_decision_in_r_biomd0000000700_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Heldt2018 - Proliferation-quiescence decisionin response to DNA damage This model is described in the article: A comprehensive model for the proliferation-quiescence decision in response to endogenous. It can be used to explore systemsbiology heldt2018 proliferation quiescence decision in dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}