Park2019 - Cetuximab resistance in colorectal cancer Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_egf",
        "label": "EGF",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.initial_egf",
        "description": "Initial EGF. Sets the initial value of bundled SBML symbol `EGF`."
      },
      {
        "name": "initial_gnb5",
        "label": "GNB5",
        "units": "native SBML value",
        "default": 0.5,
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.initial_gnb5",
        "description": "Initial GNB5. Sets the initial value of bundled SBML symbol `GNB5`."
      },
      {
        "name": "initial_meki",
        "label": "MEKi",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.initial_meki",
        "description": "Initial MEKi. Sets the initial value of bundled SBML symbol `MEKi`."
      },
      {
        "name": "initial_erki",
        "label": "ERKi",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.initial_erki",
        "description": "Initial ERKi. Sets the initial value of bundled SBML symbol `ERKi`."
      },
      {
        "name": "initial_akti",
        "label": "AKTi",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.initial_akti",
        "description": "Initial AKTi. Sets the initial value of bundled SBML symbol `AKTi`."
      },
      {
        "name": "initial_egfri",
        "label": "EGFRi",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.initial_egfri",
        "description": "Initial EGFRi. Sets the initial value of bundled SBML symbol `EGFRi`."
      }
    ],
    "outputs": [
      {
        "name": "egf",
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.egf",
        "description": "EGF observable. Maps to SBML symbol `EGF`."
      },
      {
        "name": "gnb5",
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.gnb5",
        "description": "GNB5 observable. Maps to SBML symbol `GNB5`."
      },
      {
        "name": "meki",
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.meki",
        "description": "MEKi observable. Maps to SBML symbol `MEKi`."
      },
      {
        "name": "erki",
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.erki",
        "description": "ERKi observable. Maps to SBML symbol `ERKi`."
      },
      {
        "name": "akti",
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.akti",
        "description": "AKTi observable. Maps to SBML symbol `AKTi`."
      },
      {
        "name": "egfri",
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.egfri",
        "description": "EGFRi observable. Maps to SBML symbol `EGFRi`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Park2019 - Cetuximab resistance in colorectal cancer Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model",
      "alias": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model_state"
      ],
      "from": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model_summary"
      ],
      "from": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model_species_labels"
      ],
      "from": "oncology_sbml_park2019_cetuximab_resistance_in_colorectal_canc_model1909300004_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "It's an experimental + mathematical paper explaining probable targets for Cetixumab resistance in colorectal cancer. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}