Barr2017 Dynamics Of P21 In Htert Rpe1 Cells Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_mrna_p53",
        "label": "Initial MRNA P53",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.initial_mrna_p53",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MrnaP53`."
      },
      {
        "name": "initial_mrna_p21",
        "label": "Initial MRNA P21",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.initial_mrna_p21",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MrnaP21`."
      },
      {
        "name": "initial_mrna_cy",
        "label": "Initial MRNA Cy",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.initial_mrna_cy",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MrnaCy`."
      },
      {
        "name": "initial_t_p21",
        "label": "Initial T P21",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.initial_t_p21",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `tP21`."
      },
      {
        "name": "initial_t_pcna",
        "label": "Initial T Pcna",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.initial_t_pcna",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `tPcna`."
      },
      {
        "name": "initial_a_pcna",
        "label": "Initial A Pcna",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.initial_a_pcna",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `aPcna`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.species_labels"
      },
      {
        "name": "mrna_p53",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.mrna_p53"
      },
      {
        "name": "mrna_p21",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.mrna_p21"
      },
      {
        "name": "mrna_cy",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.mrna_cy"
      },
      {
        "name": "t_p21",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.t_p21"
      },
      {
        "name": "t_pcna",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.t_pcna"
      },
      {
        "name": "a_pcna",
        "maps_to": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.a_pcna"
      }
    ]
  },
  "tags": [
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Barr2017 Dynamics Of P21 In Htert Rpe1 Cells Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model",
      "alias": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model_state"
      ],
      "from": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model_summary"
      ],
      "from": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model_species_labels"
      ],
      "from": "systemsbiology_sbml_barr2017_dynamics_of_p21_in_htert_rpe1_cells_biomd0000000660_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Barr2017 - Dynamics of p21 in hTert-RPE1cells This deteministic model reveals that abistable switch created by Cdt2, promotes irreversible S-phaseentry by keeping p21 levels low, prevents premature S-. It can be used to explore systemsbiology barr2017 dynamics of p21 in dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}