Henze2017 - A Dynamical Model for Activating and Silencing the Mitotic Checkpoint Lab

{
  "io": {
    "inputs": [],
    "outputs": [
      {
        "name": "kin_a",
        "label": "Kin A",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.kin_a",
        "description": "Tracks Kin A in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.kin_a`."
      },
      {
        "name": "kin_model_state_u",
        "label": "Kin Model state U",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.kin_model_state_u",
        "description": "Tracks Kin Model state U in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.kin_model_state_u`."
      },
      {
        "name": "apcc_cdc20",
        "label": "APCC Cdc20",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apcc_cdc20",
        "description": "Tracks APCC Cdc20 in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apcc_cdc20`."
      },
      {
        "name": "securin_separase_inhibitor",
        "label": "Securin separase inhibitor",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.securin_separase_inhibitor",
        "description": "Tracks Securin separase inhibitor in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.securin_separase_inhibitor`."
      },
      {
        "name": "apc_c_complex",
        "label": "APC/C complex",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apc_c_complex",
        "description": "Tracks APC/C complex in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apc_c_complex`."
      },
      {
        "name": "cdc20_apc_c_activator",
        "label": "Cdc20 APC/C activator",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.cdc20_apc_c_activator",
        "description": "Tracks Cdc20 APC/C activator in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.cdc20_apc_c_activator`."
      },
      {
        "name": "cyclin_b",
        "label": "Cyclin B",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.cyclin_b",
        "description": "Tracks Cyclin B in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.cyclin_b`."
      },
      {
        "name": "apcc_mcc",
        "label": "APCC MCC",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apcc_mcc",
        "description": "Tracks APCC MCC in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apcc_mcc`."
      },
      {
        "name": "mitotic_checkpoint_complex",
        "label": "Mitotic checkpoint complex",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.mitotic_checkpoint_complex",
        "description": "Tracks Mitotic checkpoint complex in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.mitotic_checkpoint_complex`."
      },
      {
        "name": "model_state_c_mad2",
        "label": "Model state C Mad2",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.model_state_c_mad2",
        "description": "Tracks Model state C Mad2 in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.model_state_c_mad2`."
      },
      {
        "name": "o_mad2",
        "label": "O Mad2",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.o_mad2",
        "description": "Tracks O Mad2 in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.o_mad2`."
      },
      {
        "name": "cdc20_model_state_c_mad2",
        "label": "Cdc20 Model state C Mad2",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.cdc20_model_state_c_mad2",
        "description": "Tracks Cdc20 Model state C Mad2 in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.cdc20_model_state_c_mad2`."
      },
      {
        "name": "bub_model_state_r1_bub3",
        "label": "Bub Model state R1 Bub3",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.bub_model_state_r1_bub3",
        "description": "Tracks Bub Model state R1 Bub3 in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.bub_model_state_r1_bub3`."
      },
      {
        "name": "mad1_mad2",
        "label": "Mad1 Mad2",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.mad1_mad2",
        "description": "Tracks Mad1 Mad2 in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.mad1_mad2`."
      },
      {
        "name": "mad1_mad2_model_state_c_mad2",
        "label": "Mad1 Mad2 Model state C Mad2",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.mad1_mad2_model_state_c_mad2",
        "description": "Tracks Mad1 Mad2 Model state C Mad2 in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.mad1_mad2_model_state_c_mad2`."
      },
      {
        "name": "bub_r1_cdc20_checkpoint_complex",
        "label": "BubR1-Cdc20 checkpoint complex",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.bub_r1_cdc20_checkpoint_complex",
        "description": "Tracks BubR1-Cdc20 checkpoint complex in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.bub_r1_cdc20_checkpoint_complex`."
      },
      {
        "name": "apcc_cdc20_model_state_c_mad2",
        "label": "APCC Cdc20 Model state C Mad2",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apcc_cdc20_model_state_c_mad2",
        "description": "Tracks APCC Cdc20 Model state C Mad2 in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apcc_cdc20_model_state_c_mad2`."
      },
      {
        "name": "apcc_bcc",
        "label": "APCC BCC",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apcc_bcc",
        "description": "Tracks APCC BCC in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apcc_bcc`."
      },
      {
        "name": "apcc_cdc20_mcc",
        "label": "APCC Cdc20 MCC",
        "maps_to": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apcc_cdc20_mcc",
        "description": "Tracks APCC Cdc20 MCC in the lab model via `cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.apcc_cdc20_mcc`."
      }
    ]
  },
  "title": "Henze2017 - A Dynamical Model for Activating and Silencing the Mitotic Checkpoint Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model_state"
      ],
      "from": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.state"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model_summary"
      ],
      "from": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.summary"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model_species_labels"
      ],
      "from": "cellcycle_sbml_henze2017_a_dynamical_model_for_activating_and_s_model1812210002_model.species_labels"
    }
  ],
  "package": "henze2017-mitotic-checkpoint",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Single-model lab wrapper for Henze2017 - A Dynamical Model for Activating and Silencing the Mitotic Checkpoint. The spindle assembly checkpoint (SAC) is an evolutionarily conserved mechanism, exclusively sensitive to the states of kinetochores attached to microtubules. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.",
  "schema_version": "2.0"
}