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Tang2010 Polyglutamate Lab

About lab

This a model from the article: Experimental and computational analysis of polyglutamine-mediated cytotoxicity. Tang MY, Proctor CJ, Woulfe J, Gray DA.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagetang2010-polyglutamate-lab
Created2026-05-17
Updated2026-05-17
cellcyclesystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_nat_p",
        "label": "Initial Nat P",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.initial_nat_p",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `NatP`."
      },
      {
        "name": "initial_p_ideath",
        "label": "Initial P Ideath",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.initial_p_ideath",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `PIdeath`."
      },
      {
        "name": "initial_p38death",
        "label": "Initial P38death",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.initial_p38death",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `p38death`."
      },
      {
        "name": "initial_proteasome",
        "label": "Initial Proteasome",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.initial_proteasome",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Proteasome`."
      },
      {
        "name": "initial_poly_q",
        "label": "Initial Poly Q",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.initial_poly_q",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `PolyQ`."
      },
      {
        "name": "initial_mrf_pu",
        "label": "Initial Mrf Pu",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.initial_mrf_pu",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mRFPu`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.species_labels"
      },
      {
        "name": "nat_p",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.nat_p"
      },
      {
        "name": "p_ideath",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.p_ideath"
      },
      {
        "name": "p38death",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.p38death"
      },
      {
        "name": "proteasome",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.proteasome"
      },
      {
        "name": "poly_q",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.poly_q"
      },
      {
        "name": "mrf_pu",
        "maps_to": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.mrf_pu"
      }
    ]
  },
  "tags": [
    "cellcycle",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Tang2010 Polyglutamate Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model",
      "alias": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model_state"
      ],
      "from": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model_summary"
      ],
      "from": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model_species_labels"
      ],
      "from": "systemsbiology_sbml_tang2010_polyglutamate_biomd0000000285_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "This a model from the article: Experimental and computational analysis of polyglutamine-mediated cytotoxicity. Tang MY, Proctor CJ, Woulfe J, Gray DA.",
  "schema_version": "2.0"
}

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