Koeller2021 - PBPK model of ICG liver function tests Lab

{
  "io": {
    "inputs": [
      {
        "name": "icg_infusion_rate_mg_per_min",
        "label": "ICG Infusion Rate Mg Per Min",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.icg_infusion_rate_mg_per_min"
      },
      {
        "name": "icg_injection_time_seconds",
        "label": "ICG Injection Time Seconds",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.icg_injection_time_seconds"
      },
      {
        "name": "liver_shunt_fraction",
        "label": "Liver Shunt Fraction",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.liver_shunt_fraction"
      },
      {
        "name": "liver_tissue_loss_fraction",
        "label": "Liver Tissue Loss Fraction",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.liver_tissue_loss_fraction"
      },
      {
        "name": "hepatic_blood_flow_scale",
        "label": "Hepatic Blood Flow Scale",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.hepatic_blood_flow_scale"
      },
      {
        "name": "oatp1b3_activity_scale",
        "label": "Oatp1b3 Activity Scale",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.oatp1b3_activity_scale"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.species_labels"
      },
      {
        "name": "icg_liver_plasma",
        "label": "ICG Liver Plasma",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.icg_liver_plasma"
      },
      {
        "name": "icg_venous_plasma",
        "label": "ICG Venous Plasma",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.icg_venous_plasma"
      },
      {
        "name": "icg_arterial_plasma",
        "label": "ICG Arterial Plasma",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.icg_arterial_plasma"
      },
      {
        "name": "icg_gastrointestinal_plasma",
        "label": "ICG Gastrointestinal Plasma",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.icg_gastrointestinal_plasma"
      },
      {
        "name": "icg_lung_plasma",
        "label": "ICG Lung Plasma",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.icg_lung_plasma"
      },
      {
        "name": "icg_portal_vein",
        "label": "ICG Portal Vein",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.icg_portal_vein"
      },
      {
        "name": "icg_liver_amount",
        "label": "ICG Liver Amount",
        "maps_to": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.icg_liver_amount"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pbpk",
    "pharmacokinetics",
    "liver",
    "physiology",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Koeller2021 - PBPK model of ICG liver function tests Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model",
      "alias": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model",
      "parameters": {
        "model_path": "data/MODEL2301090001.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model_state"
      ],
      "from": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model_summary"
      ],
      "from": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model_species_labels"
      ],
      "from": "pharmacology_sbml_koeller2021_pbpk_model_of_icg_liver_function_tes_model2301090001_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Physiollogically based pharmacokinetic (PBPK) model of indocyanine-green (ICG) liver function tests. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}