Creemers2021 - Tumor-immune dynamics and implications on immunotherapy responses Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_intratumoral_t_cells",
        "label": "Initial Intratumoral T Cells",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.initial_intratumoral_t_cells",
        "description": "Initial Intratumoral T Cells. Sets the initial value of bundled SBML species `I`."
      },
      {
        "name": "initial_tumor_cells",
        "label": "Initial Tumor Cells",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.initial_tumor_cells",
        "description": "Initial Tumor Cells. Sets the initial value of bundled SBML species `T`."
      },
      {
        "name": "initial_specific_t_cells",
        "label": "Initial Specific T Cells",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.initial_specific_t_cells",
        "description": "Initial Specific T Cells. Sets the initial value of bundled SBML species `S`."
      },
      {
        "name": "initial_naive_t_cells",
        "label": "Initial Naive T Cells",
        "units": "native source value",
        "default": 1000000,
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.initial_naive_t_cells",
        "description": "Initial Naive T Cells. Sets the initial value of bundled SBML species `N`."
      },
      {
        "name": "intratumoral_t_cell_death_rate",
        "label": "Intratumoral T Cell Death Rate",
        "units": "native source value",
        "default": 0.019,
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.intratumoral_t_cell_death_rate",
        "description": "Intratumoral T Cell Death Rate. Sets bundled SBML parameter `delta`."
      }
    ],
    "outputs": [
      {
        "name": "intratumoral_t_cells",
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.intratumoral_t_cells"
      },
      {
        "name": "tumor_cells",
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.tumor_cells"
      },
      {
        "name": "specific_t_cells",
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.specific_t_cells"
      },
      {
        "name": "naive_t_cells",
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.naive_t_cells"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.species_labels"
      }
    ]
  },
  "title": "Creemers2021 - Tumor-immune dynamics and implications on immunotherapy responses Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model",
      "alias": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model_state"
      ],
      "from": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model_summary"
      ],
      "from": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model_species_labels"
      ],
      "from": "immunology_sbml_creemers2021_tumor_immune_dynamics_and_implicati_biomd0000001022_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This ordinary differential equation model simulating the mechanisms that govern cancer-immune dynamics and their role in tumor responses to immunotherapy is described by the publication:Creemers JHA,. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}