Orton2009 - Modelling cancerous mutations in the EGFR/ERK pathway - EGF Model Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_free_egfreceptor",
        "label": "FreeEGFReceptor",
        "units": "native SBML value",
        "default": 80000,
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.initial_free_egfreceptor",
        "description": "Initial FreeEGFReceptor. Sets the initial value of bundled SBML symbol `species_1`."
      },
      {
        "name": "initial_bound_egfreceptor",
        "label": "BoundEGFReceptor",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.initial_bound_egfreceptor",
        "description": "Initial BoundEGFReceptor. Sets the initial value of bundled SBML symbol `species_0`."
      },
      {
        "name": "initial_degraded_egfreceptor",
        "label": "DegradedEGFReceptor",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.initial_degraded_egfreceptor",
        "description": "Initial DegradedEGFReceptor. Sets the initial value of bundled SBML symbol `species_18`."
      },
      {
        "name": "initial_ras_inactive",
        "label": "RasInactive",
        "units": "native SBML value",
        "default": 120000,
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.initial_ras_inactive",
        "description": "Initial RasInactive. Sets the initial value of bundled SBML symbol `species_5`."
      },
      {
        "name": "initial_raf1_inactive",
        "label": "Raf1Inactive",
        "units": "native SBML value",
        "default": 120000,
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.initial_raf1_inactive",
        "description": "Initial Raf1Inactive. Sets the initial value of bundled SBML symbol `species_7`."
      },
      {
        "name": "initial_erk_inactive",
        "label": "ErkInactive",
        "units": "native SBML value",
        "default": 600000,
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.initial_erk_inactive",
        "description": "Initial ErkInactive. Sets the initial value of bundled SBML symbol `species_11`."
      }
    ],
    "outputs": [
      {
        "name": "free_egfreceptor",
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.free_egfreceptor",
        "description": "FreeEGFReceptor observable. Maps to SBML symbol `species_1`."
      },
      {
        "name": "bound_egfreceptor",
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.bound_egfreceptor",
        "description": "BoundEGFReceptor observable. Maps to SBML symbol `species_0`."
      },
      {
        "name": "degraded_egfreceptor",
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.degraded_egfreceptor",
        "description": "DegradedEGFReceptor observable. Maps to SBML symbol `species_18`."
      },
      {
        "name": "ras_inactive",
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.ras_inactive",
        "description": "RasInactive observable. Maps to SBML symbol `species_5`."
      },
      {
        "name": "raf1_inactive",
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.raf1_inactive",
        "description": "Raf1Inactive observable. Maps to SBML symbol `species_7`."
      },
      {
        "name": "erk_inactive",
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.erk_inactive",
        "description": "ErkInactive observable. Maps to SBML symbol `species_11`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Orton2009 - Modelling cancerous mutations in the EGFR/ERK pathway - EGF Model Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model",
      "alias": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model_state"
      ],
      "from": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model_summary"
      ],
      "from": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model_species_labels"
      ],
      "from": "oncology_sbml_orton2009_modelling_cancerous_mutations_in_the_e_biomd0000000623_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Orton2009 - Modelling cancerous mutations inthe EGFR/ERK pathway - EGF Model This model studies the aberrations inERK signalling for different cancer mutations. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}