Almuallem2020 - Virus-macrophage-tumour interactions in oncolytic viral therapies Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_infected_tumour_cells",
        "label": "Initial Infected Tumour Cells",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.initial_infected_tumour_cells",
        "description": "Initial Infected Tumour Cells. Sets the initial value of bundled SBML species `Infected_tumour_cells`."
      },
      {
        "name": "initial_uninfected_tumour_cells",
        "label": "Initial Uninfected Tumour Cells",
        "units": "native source value",
        "default": 0.0005,
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.initial_uninfected_tumour_cells",
        "description": "Initial Uninfected Tumour Cells. Sets the initial value of bundled SBML species `Uninfected_tumour_cells`."
      },
      {
        "name": "initial_oncolytic_viruses",
        "label": "Initial Oncolytic Viruses",
        "units": "native source value",
        "default": 0.00001,
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.initial_oncolytic_viruses",
        "description": "Initial Oncolytic Viruses. Sets the initial value of bundled SBML species `Oncolytic_viruses`."
      },
      {
        "name": "initial_unresolved_tumor_observable_1",
        "label": "Initial Unresolved Tumor Observable 1",
        "units": "native source value",
        "default": 0.0000025,
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.initial_unresolved_tumor_observable_1",
        "description": "Initial Unresolved Tumor Observable 1. Sets the initial value of bundled SBML species `M1_macrophages`."
      },
      {
        "name": "initial_uninfected_m2_macrophages",
        "label": "Initial Uninfected M2 Macrophages",
        "units": "native source value",
        "default": 2.5e-7,
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.initial_uninfected_m2_macrophages",
        "description": "Initial Uninfected M2 Macrophages. Sets the initial value of bundled SBML species `Uninfected_M2_macrophages`."
      },
      {
        "name": "tumour_growth_production_rate",
        "label": "Tumour Growth Production Rate",
        "units": "native source value",
        "default": 0.62,
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.tumour_growth_production_rate",
        "description": "Tumour Growth Production Rate. Sets bundled SBML parameter `r`."
      }
    ],
    "outputs": [
      {
        "name": "infected_tumour_cells",
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.infected_tumour_cells"
      },
      {
        "name": "uninfected_tumour_cells",
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.uninfected_tumour_cells"
      },
      {
        "name": "oncolytic_viruses",
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.oncolytic_viruses"
      },
      {
        "name": "unresolved_tumor_observable_1",
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.unresolved_tumor_observable_1"
      },
      {
        "name": "uninfected_m2_macrophages",
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.uninfected_m2_macrophages"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.species_labels"
      }
    ]
  },
  "title": "Almuallem2020 - Virus-macrophage-tumour interactions in oncolytic viral therapies Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model_state"
      ],
      "from": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model_summary"
      ],
      "from": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model_species_labels"
      ],
      "from": "immunology_sbml_almuallem2020_virus_macrophage_tumour_interactio_biomd0000001033_model.species_labels"
    }
  ],
  "package": "almuallem2020-virus-macrophage-tumour-interactions-in-o-78e115fe",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.1",
  "description": "This mathematical model of the role of the innate immune responses generated by macrophages in the context of anti-tumour oncolytic viral therapies is described in the publication:Nada Almuallem, Dumi. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}