Tylutki2017-four-compartment PBPK heart model accounting for cardiac metabolism Lab

{
  "io": {
    "inputs": [
      {
        "name": "drug_dose",
        "label": "Drug Dose",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.drug_dose"
      },
      {
        "name": "fraction_absorbed",
        "label": "Fraction Absorbed",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.fraction_absorbed"
      },
      {
        "name": "absorption_rate",
        "label": "Absorption Rate",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.absorption_rate"
      },
      {
        "name": "renal_clearance",
        "label": "Renal Clearance",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.renal_clearance"
      },
      {
        "name": "cyp2c9_expression",
        "label": "CYP2C9 Expression",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.cyp2c9_expression"
      },
      {
        "name": "cyp2c8_expression",
        "label": "CYP2C8 Expression",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.cyp2c8_expression"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.species_labels"
      },
      {
        "name": "adipose_drug_amount",
        "label": "Adipose Drug Amount",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.adipose_drug_amount"
      },
      {
        "name": "bone_drug_amount",
        "label": "Bone Drug Amount",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.bone_drug_amount"
      },
      {
        "name": "brain_drug_amount",
        "label": "Brain Drug Amount",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.brain_drug_amount"
      },
      {
        "name": "gut_drug_amount",
        "label": "Gut Drug Amount",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.gut_drug_amount"
      },
      {
        "name": "epicardium_drug_amount",
        "label": "Epicardium Drug Amount",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.epicardium_drug_amount"
      },
      {
        "name": "myocardium_drug_amount",
        "label": "Myocardium Drug Amount",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.myocardium_drug_amount"
      },
      {
        "name": "endocardium_drug_amount",
        "label": "Endocardium Drug Amount",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.endocardium_drug_amount"
      },
      {
        "name": "perfusate_drug_amount",
        "label": "Perfusate Drug Amount",
        "maps_to": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.perfusate_drug_amount"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pbpk",
    "cardiovascular",
    "metabolism",
    "physiology",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Tylutki2017-four-compartment PBPK heart model accounting for cardiac metabolism Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model",
      "alias": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model",
      "parameters": {
        "model_path": "data/MODEL2003190003.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
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      ],
      "from": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model_summary"
      ],
      "from": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model_species_labels"
      ],
      "from": "pharmacology_sbml_tylutki2017_four_compartment_pbpk_heart_model_ac_model2003190003_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "In the field of cardiac drug efficacy and safety assessment, information on drug concentration in heart tissue is desirable. Because measuring drug concentrations in human cardiac tissue is challengin.",
  "schema_version": "2.0"
}