Zake2021 - PBPK model of metformin in humans, eight PO administrations with 12h interval Lab

{
  "io": {
    "inputs": [
      {
        "name": "metformin_lumen_dose_mg",
        "label": "Metformin Lumen Dose Mg",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.metformin_lumen_dose_mg"
      },
      {
        "name": "body_weight_g",
        "label": "Body Weight G",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.body_weight_g"
      },
      {
        "name": "cardiac_output_ml_per_min",
        "label": "Cardiac Output Ml Per Min",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.cardiac_output_ml_per_min"
      },
      {
        "name": "kidney_partition_coefficient",
        "label": "Kidney Partition Coefficient",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.kidney_partition_coefficient"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.species_labels"
      },
      {
        "name": "kidney_plasma_metformin",
        "label": "Kidney Plasma Metformin",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.kidney_plasma_metformin"
      },
      {
        "name": "liver_metformin",
        "label": "Liver Metformin",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.liver_metformin"
      },
      {
        "name": "venous_plasma_metformin",
        "label": "Venous Plasma Metformin",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.venous_plasma_metformin"
      },
      {
        "name": "arterial_plasma_metformin",
        "label": "Arterial Plasma Metformin",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.arterial_plasma_metformin"
      },
      {
        "name": "kidney_tissue_metformin",
        "label": "Kidney Tissue Metformin",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.kidney_tissue_metformin"
      },
      {
        "name": "kidney_tubular_metformin",
        "label": "Kidney Tubular Metformin",
        "maps_to": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.kidney_tubular_metformin"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pbpk",
    "pharmacokinetics",
    "endocrine",
    "physiology",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Zake2021 - PBPK model of metformin in humans, eight PO administrations with 12h interval Lab",
  "models": [
    {
      "path": "owned/models/pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model",
      "alias": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model",
      "parameters": {
        "model_path": "data/BIOMD0000001029.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model_state"
      ],
      "from": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model_summary"
      ],
      "from": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model_species_labels"
      ],
      "from": "pharmacology_sbml_zake2021_pbpk_model_of_metformin_in_humans_eight_biomd0000001029_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This model is supplementary material of publication 'Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues'by Da. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}