Chen2006 Endothelial No Release Lab

{
  "description": "Two-model lab for Chen2006 Endothelial No Release: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. Chen2006 - Nitric Oxide Release fromEndothelial Cells This model is described in the article: Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
  "io": {
    "inputs": [
      {
        "maps_to": "chen2006_endothelial_no_release_core.integration_step",
        "name": "integration_step"
      },
      {
        "maps_to": "chen2006_endothelial_no_release_core.parameter_overrides",
        "name": "parameter_overrides"
      },
      {
        "maps_to": "chen2006_endothelial_no_release_core.initial_conditions",
        "name": "initial_conditions"
      }
    ],
    "outputs": [
      {
        "maps_to": "chen2006_endothelial_no_release_scenario.scenario_metadata",
        "name": "scenario_metadata"
      },
      {
        "maps_to": "chen2006_endothelial_no_release_core.state",
        "name": "state"
      },
      {
        "maps_to": "chen2006_endothelial_no_release_viz.run_summary",
        "name": "run_summary"
      }
    ]
  },
  "models": [
    {
      "alias": "chen2006_endothelial_no_release_scenario",
      "parameters": {
        "baseline_until": 0.25,
        "challenge_until": 0.75,
        "scenario_description": "Baseline is followed by a oxygen challenge and recovery period.",
        "scenario_name": "Oxygen availability challenge",
        "schedule": {
          "arg_binding_rate": {
            "active": false,
            "baseline": 0.1,
            "challenge": 0.1,
            "description": "Scenario-controlled arg binding rate value.",
            "label": "arg binding rate",
            "recovery": 0.1,
            "unit": "dimensionless"
          },
          "l_arginine": {
            "active": false,
            "baseline": 100,
            "challenge": 100,
            "description": "Scenario-controlled l arginine value.",
            "label": "l arginine",
            "recovery": 100,
            "unit": "dimensionless"
          },
          "nitric_oxide_synthase_pool": {
            "active": false,
            "baseline": 0.015,
            "challenge": 0.015,
            "description": "Scenario-controlled nitric oxide synthase pool value.",
            "label": "nitric oxide synthase pool",
            "recovery": 0.015,
            "unit": "dimensionless"
          },
          "oxygen": {
            "active": true,
            "baseline": 150,
            "challenge": 75,
            "description": "Scenario-controlled oxygen value.",
            "label": "oxygen",
            "recovery": 150,
            "unit": "dimensionless"
          },
          "oxygen_binding_rate": {
            "active": false,
            "baseline": 1.89,
            "challenge": 1.89,
            "description": "Scenario-controlled oxygen binding rate value.",
            "label": "oxygen binding rate",
            "recovery": 1.89,
            "unit": "dimensionless"
          }
        }
      },
      "path": "models/scenario"
    },
    {
      "alias": "chen2006_endothelial_no_release_core",
      "parameters": {
        "integration_step": 0.01,
        "model_path": "data/BIOMD0000000676.xml"
      },
      "path": "models/core"
    },
    {
      "alias": "chen2006_endothelial_no_release_viz",
      "parameters": {
        "integration_step": 0.01,
        "lab_question": "Does the endothelial pathway produce nitric oxide?",
        "lab_title": "Chen2006 Endothelial No Release"
      },
      "path": "models/viz"
    }
  ],
  "package": "chen2006-endothelial-no-release",
  "runtime": {
    "communication_step": 0.01,
    "duration": 1,
    "initial_inputs": {
      "chen2006_endothelial_no_release_core": {
        "initial_conditions": {
          "payload": {}
        },
        "integration_step": 0.01,
        "parameter_overrides": {
          "payload": {}
        }
      }
    }
  },
  "schema_version": "2.0",
  "title": "Chen2006 Endothelial No Release Lab",
  "version": "1.0.0",
  "wiring": [
    {
      "from": "chen2006_endothelial_no_release_scenario.l_arginine",
      "to": [
        "chen2006_endothelial_no_release_core.l_arginine"
      ]
    },
    {
      "from": "chen2006_endothelial_no_release_scenario.oxygen",
      "to": [
        "chen2006_endothelial_no_release_core.oxygen"
      ]
    },
    {
      "from": "chen2006_endothelial_no_release_scenario.nitric_oxide_synthase_pool",
      "to": [
        "chen2006_endothelial_no_release_core.nitric_oxide_synthase_pool"
      ]
    },
    {
      "from": "chen2006_endothelial_no_release_scenario.arg_binding_rate",
      "to": [
        "chen2006_endothelial_no_release_core.arg_binding_rate"
      ]
    },
    {
      "from": "chen2006_endothelial_no_release_scenario.oxygen_binding_rate",
      "to": [
        "chen2006_endothelial_no_release_core.oxygen_binding_rate"
      ]
    },
    {
      "from": "chen2006_endothelial_no_release_scenario.scenario_metadata",
      "to": [
        "chen2006_endothelial_no_release_viz.scenario_metadata"
      ]
    },
    {
      "from": "chen2006_endothelial_no_release_core.state",
      "to": [
        "chen2006_endothelial_no_release_viz.state"
      ]
    },
    {
      "from": "chen2006_endothelial_no_release_core.species_labels",
      "to": [
        "chen2006_endothelial_no_release_viz.species_labels"
      ]
    }
  ]
}