About lab
Two-model lab for Chen2006 Endothelial No Release: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. Chen2006 - Nitric Oxide Release fromEndothelial Cells This model is described in the article: Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells. It can be used to explore cardiac dynamics and compare response patterns across conditions.
Runtime
Duration1
Comms Step0.01
Runs
Total8
Completed3
Failed5
Metadata
Packagechen2006-endothelial-no-release
Created2026-05-05
Updated2026-06-13
cardiovascularscenariostimulussbmlbiomodels_ebifaithfulvisualizationother
Manifest
{
"io": {
"inputs": [
{
"name": "integration_step",
"maps_to": "chen2006_endothelial_no_release_core.integration_step"
},
{
"name": "parameter_overrides",
"maps_to": "chen2006_endothelial_no_release_core.parameter_overrides"
},
{
"name": "initial_conditions",
"maps_to": "chen2006_endothelial_no_release_core.initial_conditions"
}
],
"outputs": [
{
"name": "scenario_metadata",
"maps_to": "chen2006_endothelial_no_release_scenario.scenario_metadata"
},
{
"name": "state",
"maps_to": "chen2006_endothelial_no_release_core.state"
},
{
"name": "run_summary",
"maps_to": "chen2006_endothelial_no_release_viz.run_summary"
}
]
},
"title": "Chen2006 Endothelial No Release Lab",
"models": [
{
"path": "models/scenario",
"alias": "chen2006_endothelial_no_release_scenario",
"parameters": {
"schedule": {
"oxygen": {
"unit": "dimensionless",
"label": "oxygen",
"active": true,
"baseline": 150,
"recovery": 150,
"challenge": 75,
"description": "Scenario-controlled oxygen value."
},
"l_arginine": {
"unit": "dimensionless",
"label": "l arginine",
"active": false,
"baseline": 100,
"recovery": 100,
"challenge": 100,
"description": "Scenario-controlled l arginine value."
},
"arg_binding_rate": {
"unit": "dimensionless",
"label": "arg binding rate",
"active": false,
"baseline": 0.1,
"recovery": 0.1,
"challenge": 0.1,
"description": "Scenario-controlled arg binding rate value."
},
"oxygen_binding_rate": {
"unit": "dimensionless",
"label": "oxygen binding rate",
"active": false,
"baseline": 1.89,
"recovery": 1.89,
"challenge": 1.89,
"description": "Scenario-controlled oxygen binding rate value."
},
"nitric_oxide_synthase_pool": {
"unit": "dimensionless",
"label": "nitric oxide synthase pool",
"active": false,
"baseline": 0.015,
"recovery": 0.015,
"challenge": 0.015,
"description": "Scenario-controlled nitric oxide synthase pool value."
}
},
"scenario_name": "Oxygen availability challenge",
"baseline_until": 0.25,
"challenge_until": 0.75,
"scenario_description": "Baseline is followed by a oxygen challenge and recovery period."
}
},
{
"path": "models/core",
"alias": "chen2006_endothelial_no_release_core",
"parameters": {
"model_path": "data/BIOMD0000000676.xml",
"integration_step": 0.01
}
},
{
"path": "models/viz",
"alias": "chen2006_endothelial_no_release_viz",
"parameters": {
"lab_title": "Chen2006 Endothelial No Release",
"lab_question": "Does the endothelial pathway produce nitric oxide?",
"integration_step": 0.01
}
}
],
"wiring": [
{
"to": [
"chen2006_endothelial_no_release_core.l_arginine"
],
"from": "chen2006_endothelial_no_release_scenario.l_arginine"
},
{
"to": [
"chen2006_endothelial_no_release_core.oxygen"
],
"from": "chen2006_endothelial_no_release_scenario.oxygen"
},
{
"to": [
"chen2006_endothelial_no_release_core.nitric_oxide_synthase_pool"
],
"from": "chen2006_endothelial_no_release_scenario.nitric_oxide_synthase_pool"
},
{
"to": [
"chen2006_endothelial_no_release_core.arg_binding_rate"
],
"from": "chen2006_endothelial_no_release_scenario.arg_binding_rate"
},
{
"to": [
"chen2006_endothelial_no_release_core.oxygen_binding_rate"
],
"from": "chen2006_endothelial_no_release_scenario.oxygen_binding_rate"
},
{
"to": [
"chen2006_endothelial_no_release_viz.scenario_metadata"
],
"from": "chen2006_endothelial_no_release_scenario.scenario_metadata"
},
{
"to": [
"chen2006_endothelial_no_release_viz.state"
],
"from": "chen2006_endothelial_no_release_core.state"
},
{
"to": [
"chen2006_endothelial_no_release_viz.species_labels"
],
"from": "chen2006_endothelial_no_release_core.species_labels"
}
],
"package": "chen2006-endothelial-no-release",
"runtime": {
"duration": 1,
"initial_inputs": {
"chen2006_endothelial_no_release_core": {
"integration_step": 0.01,
"initial_conditions": {
"payload": {}
},
"parameter_overrides": {
"payload": {}
}
}
},
"communication_step": 0.01
},
"version": "1.0.0",
"description": "Two-model lab for Chen2006 Endothelial No Release: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. Chen2006 - Nitric Oxide Release fromEndothelial Cells This model is described in the article: Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
"schema_version": "2.0"
}Sign in to start your own run. Public-lab history stays visible here.
Logs
No logs yet.
JSON
{
"communication_step": 0.01,
"dependency_installs": [
{
"alias": "chen2006_endothelial_no_release_core",
"status": "reused"
}
],
"dependency_policy_enabled": true,
"duration": 1,
"lab_commit": null,
"model_resolutions": [
{
"alias": "chen2006_endothelial_no_release_core",
"commit_sha": null,
"model_id": "/Volumes/dem-ssd/imp/projects/Nitoons/Biosimulant/models/models-cardiovascular/labs/chen2006-endothelial-no-release/models/core",
"repo_full_name": null
},
{
"alias": "chen2006_endothelial_no_release_viz",
"commit_sha": null,
"model_id": "/Volumes/dem-ssd/imp/projects/Nitoons/Biosimulant/models/models-cardiovascular/labs/chen2006-endothelial-no-release/models/viz",
"repo_full_name": null
}
],
"module_ports": {
"chen2006_endothelial_no_release_core": {
"inputs": [
"arg_binding_rate",
"initial_conditions",
"integration_step",
"l_arginine",
"nitric_oxide_synthase_pool",
"oxygen",
"oxygen_binding_rate",
"parameter_overrides"
],
"outputs": [
"species_labels",
"state"
]
},
"chen2006_endothelial_no_release_viz": {
"inputs": [
"species_labels",
"state"
],
"outputs": [
"run_summary"
]
}
},
"modules": [
"chen2006_endothelial_no_release_core",
"chen2006_endothelial_no_release_viz"
],
"outputs": {
"chen2006_endothelial_no_release_core": {
"species_labels": {
"emitted_at": 1,
"name": "species_labels",
"source": "chen2006_endothelial_no_release_core",
"spec": {
"accepted_profiles": null,
"description": "Static map of SBML species id to human-friendly label.",
"dtype": null,
"emitted_unit": null,
"interpolation": "zoh",
"kind": "state",
"max_age": null,
"schema": {
"payload": "json"
},
"shape": null,
"signal_type": "record",
"stale_policy": "warn"
},
"type": "record",
"value": {
"payload": {
"Arg": "Arg",
"Citrulline": "Citrulline",
"Fe2": "Fe2+",
"Fe2__Arg": "Fe2+_Arg",
"Fe2__NO": "Fe2+_NO",
"Fe2__NOHA": "Fe2+_NOHA",
"Fe3__Arg": "Fe3+_Arg",
"Fe3__NO": "Fe3+_NO",
"Fe3__NOHA": "Fe3+_NOHA",
"Fe3__O2__Arg": "Fe3+_O2-_Arg",
"Fe3__O2__NOHA": "Fe3+_O2-_NOHA",
"Fe3__enos": "Fe3+(enos)",
"NO": "NO",
"NOHA": "NOHA",
"O2": "O2"
}
}
},
"state": {
"emitted_at": 1,
"name": "state",
"source": "chen2006_endothelial_no_release_core",
"spec": {
"accepted_profiles": null,
"description": "Species concentrations and SBML state variables (mixed units, see SBML file).",
"dtype": null,
"emitted_unit": null,
"interpolation": "zoh",
"kind": "state",
"max_age": null,
"schema": {
"payload": "json"
},
"shape": null,
"signal_type": "record",
"stale_policy": "warn"
},
"type": "record",
"value": {
"payload": {
"Arg": 100,
"Citrulline": 0.0025683929327884776,
"Fe3__Arg": 0.007640468536507585,
"Fe3__NO": 0.0000843793868498351,
"Fe3__enos": 0.0005228776610954842,
"NO": 0.002442771941727656,
"O2": 150
}
}
}
},
"chen2006_endothelial_no_release_viz": {
"run_summary": {
"emitted_at": 1,
"name": "run_summary",
"source": "chen2006_endothelial_no_release_viz",
"spec": {
"accepted_profiles": null,
"description": "Structured Q&A record echoing the rows in the 'What Happened' table.",
"dtype": null,
"emitted_unit": null,
"interpolation": "zoh",
"kind": "state",
"max_age": null,
"schema": {
"payload": "json"
},
"shape": null,
"signal_type": "record",
"stale_policy": "warn"
},
"type": "record",
"value": {
"payload": {
"duration_s": 1,
"point_count": 99,
"rows": [
[
"What question did this run answer?",
"Does the endothelial pathway produce nitric oxide?"
],
[
"How much simulated time was evaluated?",
"1 s across 99 recorded time points"
],
[
"Which variable most strongly shaped: Does the endothelial pathway produce nitric oxide?",
"Oxygen ended at 150"
],
[
"How should this be interpreted?",
"Use the Chen2006 Endothelial No Release timeseries to inspect whether Oxygen supports or contradicts the lab question."
]
],
"state_variable_count": 7
}
}
}
}
},
"state": {
"chen2006_endothelial_no_release_core": {},
"chen2006_endothelial_no_release_viz": {}
},
"visuals": [
{
"module": "chen2006_endothelial_no_release_viz",
"module_class": "Chen2006NitricOxideReleaseFromEndothelialCBiomd0000000676ModelViz",
"visuals": [
{
"data": {
"series": [
{
"name": "Nitric oxide",
"points": [
[
0.02,
6.25902413777994e-12
],
[
0.03,
5.749564132934996e-10
],
[
0.04,
6.4029264311870575e-9
],
[
0.05,
3.158712258764063e-8
],
[
0.060000000000000005,
1.0186697454360178e-7
],
[
0.07,
2.5374039551924146e-7
],
[
0.08,
5.320679261827016e-7
],
[
0.09,
9.872905542273749e-7
],
[
0.1,
0.000001672831613959965
],
[
0.11,
0.000002642933869155989
],
[
0.11999999999999998,
0.000003950966920121522
],
[
0.12999999999999998,
0.000005648136478637485
],
[
0.14,
0.000007782651381925125
],
[
0.15,
0.000010399153607070728
],
[
0.16,
0.00001353840180492639
],
[
0.17,
0.000017237139564874934
],
[
0.18000000000000002,
0.000021528096302241166
],
[
0.19000000000000003,
0.000026440084725319585
],
[
0.20000000000000004,
0.000031998162495539676
],
[
0.21000000000000005,
0.0000382238376266598
],
[
0.22000000000000008,
0.000045135298700218464
],
[
0.2300000000000001,
0.00005274765443059066
],
[
0.24000000000000007,
0.00006107317879839093
],
[
0.25000000000000006,
0.00007012155351082354
],
[
0.26000000000000006,
0.00007990010048922083
],
[
0.2700000000000001,
0.00009041400390824136
],
[
0.2800000000000001,
0.0001016665176512888
],
[
0.2900000000000001,
0.00011365915846468246
],
[
0.3000000000000001,
0.00012639190168647194
],
[
0.3100000000000001,
0.00013986332799228925
],
[
0.3200000000000001,
0.00015407078352724007
],
[
0.3300000000000001,
0.00016901052337083328
],
[
0.34000000000000014,
0.00018467783868944968
],
[
0.35000000000000014,
0.0002010671728110668
],
[
0.36000000000000015,
0.0002181722265498627
],
[
0.37000000000000016,
0.00023598605355441173
],
[
0.38000000000000017,
0.00025450114644154316
],
[
0.3900000000000002,
0.00027370951445426794
],
[
0.4000000000000002,
0.00029360274585711745
],
[
0.4100000000000002,
0.00031417208816534404
],
[
0.4200000000000002,
0.000335408496668786
],
[
0.4300000000000002,
0.0003573026845215219
],
[
0.4400000000000002,
0.0003798451635708218
],
[
0.45000000000000023,
0.00040302628895687954
],
[
0.46000000000000024,
0.0004268363031807865
],
[
0.47000000000000025,
0.00045126536176700704
],
[
0.48000000000000026,
0.0004763035619286022
],
[
0.4900000000000002,
0.0005019409680872744
],
[
0.5000000000000002,
0.0005281676305199673
],
[
0.5100000000000002,
0.0005549736001696342
],
[
0.5200000000000002,
0.0005823489704007627
],
[
0.5300000000000002,
0.0006102839147579244
],
[
0.5400000000000003,
0.0006387685979842243
],
[
0.5500000000000003,
0.00066779328529458
],
[
0.5600000000000003,
0.0006973483222885795
],
[
0.5700000000000003,
0.0007274241441164215
],
[
0.5800000000000003,
0.0007580112797365858
],
[
0.5900000000000003,
0.0007891003555749724
],
[
0.6000000000000003,
0.000820682120612039
],
[
0.6100000000000003,
0.0008527474393848984
],
[
0.6200000000000003,
0.0008852872555269203
],
[
0.6300000000000003,
0.0009182927136976756
],
[
0.6400000000000003,
0.0009517550482469718
],
[
0.6500000000000004,
0.000985665622209846
],
[
0.6600000000000004,
0.0010200159291384164
],
[
0.6700000000000004,
0.0010547975863287003
],
[
0.6800000000000004,
0.001090002344191574
],
[
0.6900000000000004,
0.0011256220928732965
],
[
0.7000000000000004,
0.0011616488564861872
],
[
0.7100000000000004,
0.0011980747930923617
],
[
0.7200000000000004,
0.001234892194418488
],
[
0.7300000000000004,
0.001272093485333487
],
[
0.7400000000000004,
0.0013096712231211924
],
[
0.7500000000000004,
0.0013476180965746663
],
[
0.7600000000000005,
0.0013859269249349498
],
[
0.7700000000000005,
0.0014245906566986214
],
[
0.7800000000000005,
0.0014636023683104096
],
[
0.7900000000000005,
0.0015029552627593942
],
[
0.8000000000000005,
0.001542642668091858
],
[
0.8100000000000005,
0.001582658035855315
],
[
0.8200000000000005,
0.0016229949394843811
],
[
0.8300000000000005,
0.001663647072031319
],
[
0.8400000000000005,
0.0017046082383937546
],
[
0.8500000000000005,
0.001745872367509894
],
[
0.8600000000000005,
0.0017874335033526375
],
[
0.8700000000000006,
0.0018292858031521515
],
[
0.8800000000000006,
0.0018714235356070731
],
[
0.8900000000000006,
0.0019138410790872425
],
[
0.9000000000000006,
0.0019565329198321787
],
[
0.9100000000000006,
0.001999493650151141
],
[
0.9200000000000006,
0.002042717966626017
],
[
0.9300000000000006,
0.0020862006683205737
],
[
0.9400000000000006,
0.002129936649702686
],
[
0.9500000000000006,
0.0021739208940367897
],
[
0.9600000000000006,
0.0022181484977213417
],
[
0.9700000000000006,
0.002262614652583642
],
[
0.9800000000000006,
0.002307314644156494
],
[
0.9900000000000008,
0.0023522438499730533
],
[
1,
0.002397397776909387
]
]
},
{
"name": "Citrulline",
"points": [
[
0.02,
8.587067311613956e-11
],
[
0.03,
3.874980058796058e-9
],
[
0.04,
2.9140386853866017e-8
],
[
0.05,
1.109326688969491e-7
],
[
0.060000000000000005,
2.9691257121383864e-7
],
[
0.07,
6.421867409811845e-7
],
[
0.08,
0.000001205310875759562
],
[
0.09,
0.000002045413810957627
],
[
0.1,
0.0000032201922221948176
],
[
0.11,
0.000004784598594933888
],
[
0.11999999999999998,
0.000006789963197076172
],
[
0.12999999999999998,
0.00000928347568434032
],
[
0.14,
0.000012307977437142047
],
[
0.15,
0.00001590189087668486
],
[
0.16,
0.000020099289125011823
],
[
0.17,
0.000024930053425659035
],
[
0.18000000000000002,
0.00003042008466253141
],
[
0.19000000000000003,
0.000036591549305788405
],
[
0.20000000000000004,
0.000043463142052063174
],
[
0.21000000000000005,
0.00005105035530625684
],
[
0.22000000000000008,
0.000059365746121558626
],
[
0.2300000000000001,
0.00006841919356858322
],
[
0.24000000000000007,
0.00007821814665357504
],
[
0.25000000000000006,
0.00008876785881524891
],
[
0.26000000000000006,
0.00010007160623622104
],
[
0.2700000000000001,
0.0001121308906723452
],
[
0.2800000000000001,
0.00012494562659890992
],
[
0.2900000000000001,
0.00013851431564156972
],
[
0.3000000000000001,
0.00015283420507461554
],
[
0.3100000000000001,
0.0001679014257980253
],
[
0.3200000000000001,
0.00018371112507476695
],
[
0.3300000000000001,
0.00020025759042208377
],
[
0.34000000000000014,
0.00021753435529934924
],
[
0.35000000000000014,
0.00023553429641983177
],
[
0.36000000000000015,
0.0002542497216128341
],
[
0.37000000000000016,
0.00027367244901111483
],
[
0.38000000000000017,
0.0002937938782971418
],
[
0.3900000000000002,
0.0003146050546980492
],
[
0.4000000000000002,
0.00033609671829868055
],
[
0.4100000000000002,
0.00035825937446842435
],
[
0.4200000000000002,
0.00038108333090376267
],
[
0.4300000000000002,
0.00040455873824010166
],
[
0.4400000000000002,
0.0004286756221400534
],
[
0.45000000000000023,
0.0004534239204332235
],
[
0.46000000000000024,
0.0004787935203554122
],
[
0.47000000000000025,
0.000504774277474402
],
[
0.48000000000000026,
0.0005313560386138857
],
[
0.4900000000000002,
0.0005585286621877082
],
[
0.5000000000000002,
0.0005862820322163384
],
[
0.5100000000000002,
0.0006146060687035752
],
[
0.5200000000000002,
0.0006434907659652128
],
[
0.5300000000000002,
0.0006729262262503856
],
[
0.5400000000000003,
0.000702902568877686
],
[
0.5500000000000003,
0.0007334100355433149
],
[
0.5600000000000003,
0.0007644389681077723
],
[
0.5700000000000003,
0.0007959798154967606
],
[
0.5800000000000003,
0.0008280231359311445
],
[
0.5900000000000003,
0.0008605595987957167
],
[
0.6000000000000003,
0.0008935800080035667
],
[
0.6100000000000003,
0.0009270752935096196
],
[
0.6200000000000003,
0.0009610364743059406
],
[
0.6300000000000003,
0.00099545477683528
],
[
0.6400000000000003,
0.001030321524866803
],
[
0.6500000000000004,
0.0010656281767719754
],
[
0.6600000000000004,
0.001101366326492403
],
[
0.6700000000000004,
0.0011375276961443038
],
[
0.6800000000000004,
0.0011741041445422129
],
[
0.6900000000000004,
0.0012110876730849084
],
[
0.7000000000000004,
0.0012484704195422588
],
[
0.7100000000000004,
0.001286244657543065
],
[
0.7200000000000004,
0.0013244027958476008
],
[
0.7300000000000004,
0.0013629373774314407
],
[
0.7400000000000004,
0.001401841078407721
],
[
0.7500000000000004,
0.0014411067068101726
],
[
0.7600000000000005,
0.0014807272012557775
],
[
0.7700000000000005,
0.001520695629507827
],
[
0.7800000000000005,
0.0015610051869524642
],
[
0.7900000000000005,
0.0016016491950043344
],
[
0.8000000000000005,
0.001642621099451845
],
[
0.8100000000000005,
0.0016839144687541868
],
[
0.8200000000000005,
0.0017255229922987076
],
[
0.8300000000000005,
0.0017674404780303298
],
[
0.8400000000000005,
0.0018096608446918987
],
[
0.8500000000000005,
0.001852178133689483
],
[
0.8600000000000005,
0.0018949865001400023
],
[
0.8700000000000006,
0.0019380802110330868
],
[
0.8800000000000006,
0.0019814536433911496
],
[
0.8900000000000006,
0.0020251012824296067
],
[
0.9000000000000006,
0.0020690177197205508
],
[
0.9100000000000006,
0.002113197651364854
],
[
0.9200000000000006,
0.0021576358761732748
],
[
0.9300000000000006,
0.0022023272938593934
],
[
0.9400000000000006,
0.002247266898056959
],
[
0.9500000000000006,
0.002292449769802933
],
[
0.9600000000000006,
0.002337871101346705
],
[
0.9700000000000006,
0.002383526178765886
],
[
0.9800000000000006,
0.002429410380246191
],
[
0.9900000000000008,
0.002475519174382188
],
[
1,
0.0025218481567395286
]
]
},
{
"name": "Arg",
"points": [
[
0.02,
100
],
[
0.03,
100
],
[
0.04,
100
],
[
0.05,
100
],
[
0.060000000000000005,
100
],
[
0.07,
100
],
[
0.08,
100
],
[
0.09,
100
],
[
0.1,
100
],
[
0.11,
100
],
[
0.11999999999999998,
100
],
[
0.12999999999999998,
100
],
[
0.14,
100
],
[
0.15,
100
],
[
0.16,
100
],
[
0.17,
100
],
[
0.18000000000000002,
100
],
[
0.19000000000000003,
100
],
[
0.20000000000000004,
100
],
[
0.21000000000000005,
100
],
[
0.22000000000000008,
100
],
[
0.2300000000000001,
100
],
[
0.24000000000000007,
100
],
[
0.25000000000000006,
100
],
[
0.26000000000000006,
100
],
[
0.2700000000000001,
100
],
[
0.2800000000000001,
100
],
[
0.2900000000000001,
100
],
[
0.3000000000000001,
100
],
[
0.3100000000000001,
100
],
[
0.3200000000000001,
100
],
[
0.3300000000000001,
100
],
[
0.34000000000000014,
100
],
[
0.35000000000000014,
100
],
[
0.36000000000000015,
100
],
[
0.37000000000000016,
100
],
[
0.38000000000000017,
100
],
[
0.3900000000000002,
100
],
[
0.4000000000000002,
100
],
[
0.4100000000000002,
100
],
[
0.4200000000000002,
100
],
[
0.4300000000000002,
100
],
[
0.4400000000000002,
100
],
[
0.45000000000000023,
100
],
[
0.46000000000000024,
100
],
[
0.47000000000000025,
100
],
[
0.48000000000000026,
100
],
[
0.4900000000000002,
100
],
[
0.5000000000000002,
100
],
[
0.5100000000000002,
100
],
[
0.5200000000000002,
100
],
[
0.5300000000000002,
100
],
[
0.5400000000000003,
100
],
[
0.5500000000000003,
100
],
[
0.5600000000000003,
100
],
[
0.5700000000000003,
100
],
[
0.5800000000000003,
100
],
[
0.5900000000000003,
100
],
[
0.6000000000000003,
100
],
[
0.6100000000000003,
100
],
[
0.6200000000000003,
100
],
[
0.6300000000000003,
100
],
[
0.6400000000000003,
100
],
[
0.6500000000000004,
100
],
[
0.6600000000000004,
100
],
[
0.6700000000000004,
100
],
[
0.6800000000000004,
100
],
[
0.6900000000000004,
100
],
[
0.7000000000000004,
100
],
[
0.7100000000000004,
100
],
[
0.7200000000000004,
100
],
[
0.7300000000000004,
100
],
[
0.7400000000000004,
100
],
[
0.7500000000000004,
100
],
[
0.7600000000000005,
100
],
[
0.7700000000000005,
100
],
[
0.7800000000000005,
100
],
[
0.7900000000000005,
100
],
[
0.8000000000000005,
100
],
[
0.8100000000000005,
100
],
[
0.8200000000000005,
100
],
[
0.8300000000000005,
100
],
[
0.8400000000000005,
100
],
[
0.8500000000000005,
100
],
[
0.8600000000000005,
100
],
[
0.8700000000000006,
100
],
[
0.8800000000000006,
100
],
[
0.8900000000000006,
100
],
[
0.9000000000000006,
100
],
[
0.9100000000000006,
100
],
[
0.9200000000000006,
100
],
[
0.9300000000000006,
100
],
[
0.9400000000000006,
100
],
[
0.9500000000000006,
100
],
[
0.9600000000000006,
100
],
[
0.9700000000000006,
100
],
[
0.9800000000000006,
100
],
[
0.9900000000000008,
100
],
[
1,
100
]
]
},
{
"name": "Ferric endothelial nitric oxide synthase pool",
"points": [
[
0.02,
0.013450306889919552
],
[
0.03,
0.012062055824788538
],
[
0.04,
0.010818431514734751
],
[
0.05,
0.00970438096546051
],
[
0.060000000000000005,
0.008706430753282894
],
[
0.07,
0.00781252096895563
],
[
0.08,
0.007011856038585426
],
[
0.09,
0.0062947701976206385
],
[
0.1,
0.005652608585787043
],
[
0.11,
0.005077615089389066
],
[
0.11999999999999998,
0.004562842283092739
],
[
0.12999999999999998,
0.004102066736697734
],
[
0.14,
0.003689709099824629
],
[
0.15,
0.0033207680328991252
],
[
0.16,
0.0029907596747061403
],
[
0.17,
0.002695663454904473
],
[
0.18000000000000002,
0.0024318738864001163
],
[
0.19000000000000003,
0.0021961573436770883
],
[
0.20000000000000004,
0.0019856135578136327
],
[
0.21000000000000005,
0.0017976410037225127
],
[
0.22000000000000008,
0.0016299058673947208
],
[
0.2300000000000001,
0.0014803146472172038
],
[
0.24000000000000007,
0.0013469893691092523
],
[
0.25000000000000006,
0.0012282451591224875
],
[
0.26000000000000006,
0.0011225703814559125
],
[
0.2700000000000001,
0.0010286086249585945
],
[
0.2800000000000001,
0.0009451431065109556
],
[
0.2900000000000001,
0.0008710837469918171
],
[
0.3000000000000001,
0.0008054493321647488
],
[
0.3100000000000001,
0.0007473610200549356
],
[
0.3200000000000001,
0.0006960301505638093
],
[
0.3300000000000001,
0.0006507495701051022
],
[
0.34000000000000014,
0.0006108848153313405
],
[
0.35000000000000014,
0.0005758666636875771
],
[
0.36000000000000015,
0.0005451844457057083
],
[
0.37000000000000016,
0.000518380041523475
],
[
0.38000000000000017,
0.0004950424919963522
],
[
0.3900000000000002,
0.0004748031618624912
],
[
0.4000000000000002,
0.0004573311630467672
],
[
0.4100000000000002,
0.00044233009130138366
],
[
0.4200000000000002,
0.0004295341187564464
],
[
0.4300000000000002,
0.0004187048429506086
],
[
0.4400000000000002,
0.0004096283911021412
],
[
0.45000000000000023,
0.0004021130191287358
],
[
0.46000000000000024,
0.00039598695639190304
],
[
0.47000000000000025,
0.0003910962119725185
],
[
0.48000000000000026,
0.0003873027531785816
],
[
0.4900000000000002,
0.00038448287127601234
],
[
0.5000000000000002,
0.0003825257070579949
],
[
0.5100000000000002,
0.0003813318394380623
],
[
0.5200000000000002,
0.0003808123643419113
],
[
0.5300000000000002,
0.0003808877467665925
],
[
0.5400000000000003,
0.0003814866368723918
],
[
0.5500000000000003,
0.0003825452277960084
],
[
0.5600000000000003,
0.0003840064267645076
],
[
0.5700000000000003,
0.000385819165671867
],
[
0.5800000000000003,
0.0003879377643722334
],
[
0.5900000000000003,
0.0003903213702812141
],
[
0.6000000000000003,
0.0003929335472677337
],
[
0.6100000000000003,
0.00039574175736324386
],
[
0.6200000000000003,
0.0003987169594394994
],
[
0.6300000000000003,
0.00040183324032615534
],
[
0.6400000000000003,
0.0004050675135077824
],
[
0.6500000000000004,
0.00040839921519857786
],
[
0.6600000000000004,
0.00041181004383865913
],
[
0.6700000000000004,
0.0004152837245998888
],
[
0.6800000000000004,
0.0004188058019869504
],
[
0.6900000000000004,
0.0004223634520704378
],
[
0.7000000000000004,
0.00042594531159302233
],
[
0.7100000000000004,
0.0004295413260048922
],
[
0.7200000000000004,
0.0004331426130603864
],
[
0.7300000000000004,
0.0004367413403910712
],
[
0.7400000000000004,
0.00044033061563070056
],
[
0.7500000000000004,
0.0004439043878111712
],
[
0.7600000000000005,
0.00044745735887839847
],
[
0.7700000000000005,
0.0004509849042938917
],
[
0.7800000000000005,
0.00045448300179288007
],
[
0.7900000000000005,
0.0004579481674645671
],
[
0.8000000000000005,
0.0004613773984052629
],
[
0.8100000000000005,
0.0004647681212715969
],
[
0.8200000000000005,
0.00046811814612985567
],
[
0.8300000000000005,
0.0004714256248085887
],
[
0.8400000000000005,
0.0004746890117990046
],
[
0.8500000000000005,
0.00047790703686493457
],
[
0.8600000000000005,
0.00048107867127403654
],
[
0.8700000000000006,
0.0004842031010578967
],
[
0.8800000000000006,
0.000487279703037334
],
[
0.8900000000000006,
0.0004903080233303008
],
[
0.9000000000000006,
0.000493287758088426
],
[
0.9100000000000006,
0.0004962187362338027
],
[
0.9200000000000006,
0.0004991009039916467
],
[
0.9300000000000006,
0.000501934311034937
],
[
0.9400000000000006,
0.0005047190991035506
],
[
0.9500000000000006,
0.0005074554919150864
],
[
0.9600000000000006,
0.0005101437801411683
],
[
0.9700000000000006,
0.000512784315514317
],
[
0.9800000000000006,
0.0005153775028728616
],
[
0.9900000000000008,
0.0005179237930481087
],
[
1,
0.0005204236681417263
]
]
},
{
"name": "Oxygen",
"points": [
[
0.02,
150
],
[
0.03,
150
],
[
0.04,
150
],
[
0.05,
150
],
[
0.060000000000000005,
150
],
[
0.07,
150
],
[
0.08,
150
],
[
0.09,
150
],
[
0.1,
150
],
[
0.11,
150
],
[
0.11999999999999998,
150
],
[
0.12999999999999998,
150
],
[
0.14,
150
],
[
0.15,
150
],
[
0.16,
150
],
[
0.17,
150
],
[
0.18000000000000002,
150
],
[
0.19000000000000003,
150
],
[
0.20000000000000004,
150
],
[
0.21000000000000005,
150
],
[
0.22000000000000008,
150
],
[
0.2300000000000001,
150
],
[
0.24000000000000007,
150
],
[
0.25000000000000006,
150
],
[
0.26000000000000006,
150
],
[
0.2700000000000001,
150
],
[
0.2800000000000001,
150
],
[
0.2900000000000001,
150
],
[
0.3000000000000001,
150
],
[
0.3100000000000001,
150
],
[
0.3200000000000001,
150
],
[
0.3300000000000001,
150
],
[
0.34000000000000014,
150
],
[
0.35000000000000014,
150
],
[
0.36000000000000015,
150
],
[
0.37000000000000016,
150
],
[
0.38000000000000017,
150
],
[
0.3900000000000002,
150
],
[
0.4000000000000002,
150
],
[
0.4100000000000002,
150
],
[
0.4200000000000002,
150
],
[
0.4300000000000002,
150
],
[
0.4400000000000002,
150
],
[
0.45000000000000023,
150
],
[
0.46000000000000024,
150
],
[
0.47000000000000025,
150
],
[
0.48000000000000026,
150
],
[
0.4900000000000002,
150
],
[
0.5000000000000002,
150
],
[
0.5100000000000002,
150
],
[
0.5200000000000002,
150
],
[
0.5300000000000002,
150
],
[
0.5400000000000003,
150
],
[
0.5500000000000003,
150
],
[
0.5600000000000003,
150
],
[
0.5700000000000003,
150
],
[
0.5800000000000003,
150
],
[
0.5900000000000003,
150
],
[
0.6000000000000003,
150
],
[
0.6100000000000003,
150
],
[
0.6200000000000003,
150
],
[
0.6300000000000003,
150
],
[
0.6400000000000003,
150
],
[
0.6500000000000004,
150
],
[
0.6600000000000004,
150
],
[
0.6700000000000004,
150
],
[
0.6800000000000004,
150
],
[
0.6900000000000004,
150
],
[
0.7000000000000004,
150
],
[
0.7100000000000004,
150
],
[
0.7200000000000004,
150
],
[
0.7300000000000004,
150
],
[
0.7400000000000004,
150
],
[
0.7500000000000004,
150
],
[
0.7600000000000005,
150
],
[
0.7700000000000005,
150
],
[
0.7800000000000005,
150
],
[
0.7900000000000005,
150
],
[
0.8000000000000005,
150
],
[
0.8100000000000005,
150
],
[
0.8200000000000005,
150
],
[
0.8300000000000005,
150
],
[
0.8400000000000005,
150
],
[
0.8500000000000005,
150
],
[
0.8600000000000005,
150
],
[
0.8700000000000006,
150
],
[
0.8800000000000006,
150
],
[
0.8900000000000006,
150
],
[
0.9000000000000006,
150
],
[
0.9100000000000006,
150
],
[
0.9200000000000006,
150
],
[
0.9300000000000006,
150
],
[
0.9400000000000006,
150
],
[
0.9500000000000006,
150
],
[
0.9600000000000006,
150
],
[
0.9700000000000006,
150
],
[
0.9800000000000006,
150
],
[
0.9900000000000008,
150
],
[
1,
150
]
]
},
{
"name": "Arginine-bound nitric oxide synthase",
"points": [
[
0.02,
0.001413812730320756
],
[
0.03,
0.0026674207048624755
],
[
0.04,
0.003777643402215943
],
[
0.05,
0.004759547635535694
],
[
0.060000000000000005,
0.0056266310496682435
],
[
0.07,
0.006390987100398959
],
[
0.08,
0.007063451861085666
],
[
0.09,
0.007653735824981788
],
[
0.1,
0.008170540286102607
],
[
0.11,
0.008621667436033625
],
[
0.11999999999999998,
0.009014108797324968
],
[
0.12999999999999998,
0.009354128738476035
],
[
0.14,
0.009647343649069795
],
[
0.15,
0.00989878753332822
],
[
0.16,
0.010112972317770624
],
[
0.17,
0.010293941994285403
],
[
0.18000000000000002,
0.01044532091096242
],
[
0.19000000000000003,
0.01057035716758129
],
[
0.20000000000000004,
0.010671961354259608
],
[
0.21000000000000005,
0.010752741434886106
],
[
0.22000000000000008,
0.010815034068982642
],
[
0.2300000000000001,
0.010860932306800209
],
[
0.24000000000000007,
0.01089231067003357
],
[
0.25000000000000006,
0.010910847865113852
],
[
0.26000000000000006,
0.010918046918697489
],
[
0.2700000000000001,
0.010915253447380684
],
[
0.2800000000000001,
0.010903671499439448
],
[
0.2900000000000001,
0.010884376722444616
],
[
0.3000000000000001,
0.01085833435958966
],
[
0.3100000000000001,
0.01082640597190644
],
[
0.3200000000000001,
0.0107893617871606
],
[
0.3300000000000001,
0.010747889550397358
],
[
0.34000000000000014,
0.010702603474660862
],
[
0.35000000000000014,
0.01065405182071122
],
[
0.36000000000000015,
0.010602723702416956
],
[
0.37000000000000016,
0.010549055196275643
],
[
0.38000000000000017,
0.010493434825607054
],
[
0.3900000000000002,
0.010436208482836764
],
[
0.4000000000000002,
0.010377684063121026
],
[
0.4100000000000002,
0.010318134842689074
],
[
0.4200000000000002,
0.01025780342394613
],
[
0.4300000000000002,
0.01019690493939586
],
[
0.4400000000000002,
0.010135629984905092
],
[
0.45000000000000023,
0.010074147073964089
],
[
0.46000000000000024,
0.01001260484893664
],
[
0.47000000000000025,
0.009951134291702015
],
[
0.48000000000000026,
0.009889850574356023
],
[
0.4900000000000002,
0.00982885471916118
],
[
0.5000000000000002,
0.009768235086956916
],
[
0.5100000000000002,
0.009708068795608557
],
[
0.5200000000000002,
0.009648422712160052
],
[
0.5300000000000002,
0.009589354659802587
],
[
0.5400000000000003,
0.009530914396855874
],
[
0.5500000000000003,
0.00947314447496786
],
[
0.5600000000000003,
0.00941608101212117
],
[
0.5700000000000003,
0.009359754389295124
],
[
0.5800000000000003,
0.00930418988512363
],
[
0.5900000000000003,
0.009249408234288188
],
[
0.6000000000000003,
0.009195426083530325
],
[
0.6100000000000003,
0.00914225648657416
],
[
0.6200000000000003,
0.009089909222686354
],
[
0.6300000000000003,
0.009038391412818822
],
[
0.6400000000000003,
0.008987707584084261
],
[
0.6500000000000004,
0.008937860049567979
],
[
0.6600000000000004,
0.008888849168145469
],
[
0.6700000000000004,
0.008840673561832038
],
[
0.6800000000000004,
0.00879333033909225
],
[
0.6900000000000004,
0.008746815293145388
],
[
0.7000000000000004,
0.00870112305793084
],
[
0.7100000000000004,
0.008656247257436743
],
[
0.7200000000000004,
0.008612180639181111
],
[
0.7300000000000004,
0.008568915193469102
],
[
0.7400000000000004,
0.008526442259892707
],
[
0.7500000000000004,
0.008484752622386973
],
[
0.7600000000000005,
0.008443836594020957
],
[
0.7700000000000005,
0.008403684092590246
],
[
0.7800000000000005,
0.008364284707957508
],
[
0.7900000000000005,
0.008325627761999426
],
[
0.8000000000000005,
0.008287702361923032
],
[
0.8100000000000005,
0.008250497447642653
],
[
0.8200000000000005,
0.008214001833832753
],
[
0.8300000000000005,
0.008178204246197808
],
[
0.8400000000000005,
0.008143093343829327
],
[
0.8500000000000005,
0.008108657771447645
],
[
0.8600000000000005,
0.008074886173971776
],
[
0.8700000000000006,
0.008041767219160723
],
[
0.8800000000000006,
0.008009289617513692
],
[
0.8900000000000006,
0.007977442139712819
],
[
0.9000000000000006,
0.007946213631866445
],
[
0.9100000000000006,
0.007915593028789452
],
[
0.9200000000000006,
0.007885569365524018
],
[
0.9300000000000006,
0.007856131787288528
],
[
0.9400000000000006,
0.007827269545981121
],
[
0.9500000000000006,
0.00779897199638946
],
[
0.9600000000000006,
0.007771228661709107
],
[
0.9700000000000006,
0.007744029202517032
],
[
0.9800000000000006,
0.00771736342105681
],
[
0.9900000000000008,
0.007691221264732646
],
[
1,
0.007665592918449278
]
]
},
{
"name": "Nitric-oxide-bound nitric oxide synthase",
"points": [
[
0.02,
7.950597714225347e-11
],
[
0.03,
3.2903165891742134e-9
],
[
0.04,
2.262935906734683e-8
],
[
0.05,
7.881225722665962e-8
],
[
0.060000000000000005,
1.9332576463248777e-7
],
[
0.07,
3.8416241670642394e-7
],
[
0.08,
6.642599845893609e-7
],
[
0.09,
0.0000010414547149056344
],
[
0.1,
0.000001519117996570593
],
[
0.11,
0.00000209704376435059
],
[
0.11999999999999998,
0.000002772291640640909
],
[
0.12999999999999998,
0.000003539981057362199
],
[
0.14,
0.000004393930642275325
],
[
0.15,
0.000005327167143780459
],
[
0.16,
0.000006332316900002254
],
[
0.17,
0.000007401897218779712
],
[
0.18000000000000002,
0.000008528526994148497
],
[
0.19000000000000003,
0.000009705073539651735
],
[
0.20000000000000004,
0.000010924750839066342
],
[
0.21000000000000005,
0.000012181180161224896
],
[
0.22000000000000008,
0.00001346842289783001
],
[
0.2300000000000001,
0.000014780994322930698
],
[
0.24000000000000007,
0.000016113862239107434
],
[
0.25000000000000006,
0.000017462434920476444
],
[
0.26000000000000006,
0.000018822543011467965
],
[
0.2700000000000001,
0.000020190416568250453
],
[
0.2800000000000001,
0.00002156266124701497
],
[
0.2900000000000001,
0.000022936236319691313
],
[
0.3000000000000001,
0.000024308414138891375
],
[
0.3100000000000001,
0.00002567676889158054
],
[
0.3200000000000001,
0.000027039146500962975
],
[
0.3300000000000001,
0.000028393642630703755
],
[
0.34000000000000014,
0.000029738579073583984
],
[
0.35000000000000014,
0.00003107248302883766
],
[
0.36000000000000015,
0.00003239406786148016
],
[
0.37000000000000016,
0.00003370221533175863
],
[
0.38000000000000017,
0.000034995959253338884
],
[
0.3900000000000002,
0.00003627447051922866
],
[
0.4000000000000002,
0.00003753704296605343
],
[
0.4100000000000002,
0.000038783082217172
],
[
0.4200000000000002,
0.00004001209338212706
],
[
0.4300000000000002,
0.0000412236707331515
],
[
0.4400000000000002,
0.00004241748827517881
],
[
0.45000000000000023,
0.00004359329153291618
],
[
0.46000000000000024,
0.00004475088997806703
],
[
0.47000000000000025,
0.000045890149859380584
],
[
0.48000000000000026,
0.000047010987977398025
],
[
0.4900000000000002,
0.00004811336606779132
],
[
0.5000000000000002,
0.00004919728585642341
],
[
0.5100000000000002,
0.000050262784375232945
],
[
0.5200000000000002,
0.0000513099298304117
],
[
0.5300000000000002,
0.000052338816827717226
],
[
0.5400000000000003,
0.000053349565992429615
],
[
0.5500000000000003,
0.00005434231815934583
],
[
0.5600000000000003,
0.000055317232585749
],
[
0.5700000000000003,
0.00005627448453161987
],
[
0.5800000000000003,
0.00005721426316004435
],
[
0.5900000000000003,
0.00005813676968506265
],
[
0.6000000000000003,
0.00005904221522535013
],
[
0.6100000000000003,
0.00005993081943380707
],
[
0.6200000000000003,
0.000060802810568825376
],
[
0.6300000000000003,
0.0000616584199193322
],
[
0.6400000000000003,
0.0000624978848961815
],
[
0.6500000000000004,
0.00006332144665469064
],
[
0.6600000000000004,
0.00006412934919970228
],
[
0.6700000000000004,
0.00006492183887758632
],
[
0.6800000000000004,
0.00006569916337078058
],
[
0.6900000000000004,
0.0000664615708514125
],
[
0.7000000000000004,
0.00006720930963487453
],
[
0.7100000000000004,
0.00006794262768420704
],
[
0.7200000000000004,
0.0000686617721726951
],
[
0.7300000000000004,
0.00006936698909881513
],
[
0.7400000000000004,
0.00007005852294811741
],
[
0.7500000000000004,
0.00007073661639723078
],
[
0.7600000000000005,
0.00007140151005569038
],
[
0.7700000000000005,
0.00007205344224156514
],
[
0.7800000000000005,
0.0000726926487874619
],
[
0.7900000000000005,
0.00007331936287367639
],
[
0.8000000000000005,
0.00007393381488570698
],
[
0.8100000000000005,
0.00007453623229352039
],
[
0.8200000000000005,
0.00007512683955030261
],
[
0.8300000000000005,
0.00007570585802964866
],
[
0.8400000000000005,
0.00007627350616941661
],
[
0.8500000000000005,
0.0000768299989359137
],
[
0.8600000000000005,
0.00007737554802946158
],
[
0.8700000000000006,
0.00007791036185368955
],
[
0.8800000000000006,
0.00007843464549460518
],
[
0.8900000000000006,
0.00007894860070842318
],
[
0.9000000000000006,
0.00007945242591717785
],
[
0.9100000000000006,
0.00007994631621116058
],
[
0.9200000000000006,
0.00008043046335746772
],
[
0.9300000000000006,
0.00008090505581392611
],
[
0.9400000000000006,
0.000081370278943708
],
[
0.9500000000000006,
0.00008182631521746973
],
[
0.9600000000000006,
0.00008227334327422326
],
[
0.9700000000000006,
0.00008271153854122072
],
[
0.9800000000000006,
0.00008314107326627487
],
[
0.9900000000000008,
0.00008356211655244667
],
[
1,
0.00008397483294725535
]
]
}
],
"title": "Does the endothelial pathway produce nitric oxide?"
},
"description": "Does the endothelial pathway produce nitric oxide? — state variables tracked through the run.",
"render": "timeseries"
},
{
"data": {
"columns": [
"Question",
"Answer"
],
"rows": [
[
"What question did this run answer?",
"Does the endothelial pathway produce nitric oxide?"
],
[
"How much simulated time was evaluated?",
"1 s across 99 recorded time points"
],
[
"Which variable most strongly shaped: Does the endothelial pathway produce nitric oxide?",
"Oxygen ended at 150"
],
[
"How should this be interpreted?",
"Use the Chen2006 Endothelial No Release timeseries to inspect whether Oxygen supports or contradicts the lab question."
]
],
"subtitle": "Does the endothelial pathway produce nitric oxide? (A 1-second window of the Chen2006 Endothelial No Release model, integrated by Tellurium.)",
"title": "What Happened"
},
"description": "Answers `Does the endothelial pathway produce nitric oxide?` for the Chen2006 Endothelial No Release run.",
"render": "table"
}
]
}
]
}