Alharbi2020 - An ODE-based model of the dynamics of tumor cell progression and its effects on normal cell growth and immune system functionality Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_tumor_cells",
        "label": "Initial Tumor Cells",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.initial_tumor_cells",
        "description": "Initial Tumor Cells. Sets the initial value of bundled SBML species `Tumor_cells`."
      },
      {
        "name": "initial_immune_cells",
        "label": "Initial Immune Cells",
        "units": "native source value",
        "default": 1.22,
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.initial_immune_cells",
        "description": "Initial Immune Cells. Sets the initial value of bundled SBML species `Immune_cells`."
      },
      {
        "name": "initial_normal_cells",
        "label": "Initial Normal Cells",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.initial_normal_cells",
        "description": "Initial Normal Cells. Sets the initial value of bundled SBML species `Normal_cells`."
      },
      {
        "name": "normal_cell_growth_rate",
        "label": "Normal Cell Growth Rate",
        "units": "native source value",
        "default": 0.4312,
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.normal_cell_growth_rate",
        "description": "Normal Cell Growth Rate. Sets bundled SBML parameter `r`."
      },
      {
        "name": "normal_cell_growth_rate_2",
        "label": "Normal Cell Growth Rate 2",
        "units": "native source value",
        "default": 0.00000299,
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.normal_cell_growth_rate_2",
        "description": "Normal Cell Growth Rate 2. Sets bundled SBML parameter `beta_1`."
      },
      {
        "name": "normal_cell_death_inhibition_rate",
        "label": "Normal Cell Death Inhibition Rate",
        "units": "native source value",
        "default": 0.9314,
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.normal_cell_death_inhibition_rate",
        "description": "Normal Cell Death Inhibition Rate. Sets bundled SBML parameter `gamma`."
      },
      {
        "name": "tumor_cell_growth_rate",
        "label": "Tumor Cell Growth Rate",
        "units": "native source value",
        "default": 0.4426,
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.tumor_cell_growth_rate",
        "description": "Tumor Cell Growth Rate. Sets bundled SBML parameter `alpha_1`."
      },
      {
        "name": "tumor_cell_growth_rate_2",
        "label": "Tumor Cell Growth Rate 2",
        "units": "native source value",
        "default": 0.4,
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.tumor_cell_growth_rate_2",
        "description": "Tumor Cell Growth Rate 2. Sets bundled SBML parameter `alpha_2`."
      }
    ],
    "outputs": [
      {
        "name": "tumor_cells",
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.tumor_cells"
      },
      {
        "name": "immune_cells",
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.immune_cells"
      },
      {
        "name": "normal_cells",
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.normal_cells"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.species_labels"
      }
    ]
  },
  "title": "Alharbi2020 - An ODE-based model of the dynamics of tumor cell progression and its effects on normal cell growth and immune system functionality Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model",
      "alias": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model_state"
      ],
      "from": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model_summary"
      ],
      "from": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model_species_labels"
      ],
      "from": "immunology_sbml_alharbi2020_an_ode_based_model_of_the_dynamics_o_biomd0000001023_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This ordinary differential equation model of tumor cell growth, called the normal-tumor-immune-unhealthy diet model (NTIUNHDM), is described by the publication:Alharbi, S.A.; Rambely, A.S.'A New ODE-B. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}