Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation Lab

About lab

Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation

This Biosimulant lab wraps Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation as a runnable systems biology model with a companion visualization module. Mathematical model of blood coagulation. It can be used to explore the configured dynamics and compare scenario outcomes across configurations.

What You'll See

The lab asks: Which source-defined system states dominate this SBML model trajectory? Source model: Mitrophanov2016 - Extended Mitrophanov2011 Blood Coagulation Model (additional thrombin reactions). It runs for 1.0 time units with a communication step of 0.1. The run uses the model defaults declared by the curated SBML wrapper. The generated visualizations focus on alpha_2_M, rVIIa, mIIa_ATIII, mIIa, Xa_Va_II, and Xa_Va, combining trajectory, endpoint-comparison, and summary-table views from one completed dark-mode run.

In this captured run, mIIa moved from 0 to 6.93e-27 across 1.0 simulation windows.

Output Visualizations

Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation - run interpretation

Summary table for Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation, reporting the scientific question, observed answer, dominant module, and caveat.

Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation - timeseries visualization

Trajectories of mIIa, Xa_Va, Xa_Va_II, mIIa_ATIII, alpha_2_M, and rVIIa across the 1.0 simulation. In this run mIIa climbed from 0 to 6.93e-27 — the largest movements among the focused observables.

Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation - excursions bar

Largest-excursion ranking of the focused observables — the absolute movement magnitude during the run. Top 3: mIIa = 6.93e-27, Xa_Va = 1.09e-27, Xa_Va_II = 1.04e-27, with 1 more observable below.

Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation - endpoint snapshot bar

Endpoint snapshot of the focused observables — final values from the captured run. Top 3 by value: alpha_2_M = 1.01e-06, rVIIa = 4.61e-08, mIIa = 6.93e-27, with 3 more observables below.

Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation - visualization

Visualization card from the Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation dark-mode run.

Model Context

Core model: models/core
Visualization model: models/visualisation
Standard: other
Upstream source: biomodels_ebi:MODEL1806280001
License: CC0

Inputs

Input	Maps To	Notes
Initial Alpha 2 M	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.initial_alpha_2_m`	Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `alpha_2_M`.
Initial R Vi Ia	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.initial_r_vi_ia`	Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `rVIIa`.
Initial M I Ia Atiii	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.initial_m_i_ia_atiii`	Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mIIa_ATIII`.
Initial M I Ia	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.initial_m_i_ia`	Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mIIa`.
Initial Xa Va Ii	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.initial_xa_va_ii`	Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_Va_II`.
Initial Xa Va	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.initial_xa_va`	Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_Va`.

Outputs

Output	Maps To	Role
`state`	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.state`	Available to the visualization model and downstream workflows.
`summary`	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.summary`	Available to the visualization model and downstream workflows.
`species_labels`	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.species_labels`	Available to the visualization model and downstream workflows.
`alpha_2_m`	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.alpha_2_m`	Available to the visualization model and downstream workflows.
`r_vi_ia`	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.r_vi_ia`	Available to the visualization model and downstream workflows.
`m_i_ia_atiii`	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.m_i_ia_atiii`	Available to the visualization model and downstream workflows.
`m_i_ia`	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.m_i_ia`	Available to the visualization model and downstream workflows.
`xa_va_ii`	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.xa_va_ii`	Available to the visualization model and downstream workflows.
`xa_va`	`systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.xa_va`	Available to the visualization model and downstream workflows.

Runtime

Duration: 1.0
Communication step: 0.1

Running Locally

biosimulant labs serve

Mathematical model of blood coagulation. Extended model of Mitrophanov2011 (which is an extension of Hockin2002).

Runtime

Duration1

Comms Step0.1

Runs

Total0

Completed0

Failed0

Metadata

Packagemitrophanov2016-extended-mitrophanov2011-blood-coagulation-lab

Created2026-05-17

Updated2026-05-17

systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
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        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `alpha_2_M`."
      },
      {
        "name": "initial_r_vi_ia",
        "label": "Initial R Vi Ia",
        "maps_to": "systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.initial_r_vi_ia",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `rVIIa`."
      },
      {
        "name": "initial_m_i_ia_atiii",
        "label": "Initial M I Ia Atiii",
        "maps_to": "systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.initial_m_i_ia_atiii",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mIIa_ATIII`."
      },
      {
        "name": "initial_m_i_ia",
        "label": "Initial M I Ia",
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        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mIIa`."
      },
      {
        "name": "initial_xa_va_ii",
        "label": "Initial Xa Va Ii",
        "maps_to": "systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.initial_xa_va_ii",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_Va_II`."
      },
      {
        "name": "initial_xa_va",
        "label": "Initial Xa Va",
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        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_Va`."
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      },
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      },
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        "name": "r_vi_ia",
        "maps_to": "systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.r_vi_ia"
      },
      {
        "name": "m_i_ia_atiii",
        "maps_to": "systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.m_i_ia_atiii"
      },
      {
        "name": "m_i_ia",
        "maps_to": "systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.m_i_ia"
      },
      {
        "name": "xa_va_ii",
        "maps_to": "systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.xa_va_ii"
      },
      {
        "name": "xa_va",
        "maps_to": "systemsbiology_sbml_mitrophanov2016_extended_mitrophanov2011_blood_c_model1806280001_model.xa_va"
      }
    ]
  },
  "tags": [
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Mitrophanov2016 Extended Mitrophanov2011 Blood Coagulation Lab",
  "models": [
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  "description": "Mathematical model of blood coagulation. Extended model of Mitrophanov2011 (which is an extension of Hockin2002).",
  "schema_version": "2.0"
}

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