About lab
Koo et al. (2013) model of how laminar shear stress at the endothelial surface drives calcium influx and activates endothelial nitric oxide synthase (eNOS).
Runtime
Duration600
Comms Step10
Runs
Total3
Completed3
Failed0
Metadata
Packagekoo2013-shear-stress-induced-calcium-influx-and-enos-activation
Created2026-05-04
Updated2026-05-14
biomechanicsendothelialshear-stressmechanotransductioncalciumsbmlbiomodels_ebifaithfulvisualisationkoo2013
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],
"title": "Koo2013 Shear-Stress Induced Calcium Influx and eNOS Activation - Calcium subsystem",
"x_unit": "s"
},
"description": "How do calcium pools, IP3, and calmodulin shift?",
"render": "timeseries"
},
{
"data": {
"categories": [
"Stored calcium",
"Buffered calcium",
"Cytosolic calcium",
"Step timer",
"IP3",
"Extracellular calcium",
"Shear stress"
],
"title": "Koo2013 Shear-Stress Induced Calcium Influx and eNOS Activation - largest excursions during the run",
"values": [
2396408.364521639,
28472.349823786026,
993.1340073370588,
590.0000000000002,
26.396484732626927,
0,
0
]
},
"description": "Which observables shifted the most during the run?",
"render": "bar"
},
{
"data": {
"columns": [
"Question",
"Answer"
],
"rows": [
[
"What did this run track?",
"7 observables in Koo2013 Shear-Stress Induced Calcium Influx and eNOS Activation"
],
[
"How long did it run?",
"590 s"
],
[
"Which observable changed the most?",
"Stored calcium"
],
[
"Largest peak?",
"Stored calcium"
]
],
"title": "What Happened"
},
"description": "What did this simulation actually show, in plain language?",
"render": "table"
}
]
}
]
}