Jiao2018 - Feedback regulation in a stem cell model with acute myeloid leukaemia Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_s_hsc",
        "label": "S HSC",
        "units": "native SBML value",
        "default": 10,
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.initial_s_hsc",
        "description": "Initial S HSC. Sets the initial value of bundled SBML symbol `S_HSC`."
      },
      {
        "name": "initial_a_pc",
        "label": "A PC",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.initial_a_pc",
        "description": "Initial A PC. Sets the initial value of bundled SBML symbol `A_PC`."
      },
      {
        "name": "initial_l_lsc",
        "label": "L LSC",
        "units": "native SBML value",
        "default": 10,
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.initial_l_lsc",
        "description": "Initial L LSC. Sets the initial value of bundled SBML symbol `L_LSC`."
      },
      {
        "name": "initial_d_tdsc",
        "label": "D TDSC",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.initial_d_tdsc",
        "description": "Initial D TDSC. Sets the initial value of bundled SBML symbol `D_TDSC`."
      },
      {
        "name": "initial_t_tdlc",
        "label": "T TDLC",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.initial_t_tdlc",
        "description": "Initial T TDLC. Sets the initial value of bundled SBML symbol `T_TDLC`."
      }
    ],
    "outputs": [
      {
        "name": "s_hsc",
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.s_hsc",
        "description": "S HSC observable. Maps to SBML symbol `S_HSC`."
      },
      {
        "name": "a_pc",
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.a_pc",
        "description": "A PC observable. Maps to SBML symbol `A_PC`."
      },
      {
        "name": "l_lsc",
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.l_lsc",
        "description": "L LSC observable. Maps to SBML symbol `L_LSC`."
      },
      {
        "name": "d_tdsc",
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.d_tdsc",
        "description": "D TDSC observable. Maps to SBML symbol `D_TDSC`."
      },
      {
        "name": "t_tdlc",
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.t_tdlc",
        "description": "T TDLC observable. Maps to SBML symbol `T_TDLC`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Jiao2018 - Feedback regulation in a stem cell model with acute myeloid leukaemia Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model_state"
      ],
      "from": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model_summary"
      ],
      "from": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model_species_labels"
      ],
      "from": "oncology_sbml_jiao2018_feedback_regulation_in_a_stem_cell_mode_biomd0000000898_model.species_labels"
    }
  ],
  "package": "jiao2018-feedback-regulation-in-a-stem-cell-with-acute-d05aeec8",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This is a mathematical model describing the hematopoietic lineages with leukemia lineages, as controlled by end-product negative feedback inhibition. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}