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Tolic2000 - Glucose Insulin Lab

About lab

Tolic2000 - Glucose Insulin Lab

Scientific Source

  • Source type: PhysioMe CellML
  • Upstream ID: physiome:tolic_mosekilde_sturis_2000
  • Original URL: https://models.physiomeproject.org/workspace/tolic_mosekilde_sturis_2000
  • Bundled artifact: data/tolic_mosekilde_sturis_2000.cellml

The bundled CellML/SBML artifact remains the scientific source of truth. This cleanup does not rewrite equations, parameters, units, or initial values; it exposes selected source symbols with conservative user-facing names.

Public Interface

Source-backed inputs:

  • initial_glucose_g (Glucose G) maps to source symbol G; units: mg; evidence: source symbol, component, or units provide a direct public name.
  • initial_delay_x1 (Delay X1) maps to source symbol x1; units: min; evidence: source symbol, component, or units provide a direct public name.
  • The simulator still uses an internal integration_step parameter from the model manifest; it is not exposed as a biological lab input.

Selected outputs:

  • state, summary, trajectory, and variable_labels remain available for traceability.
  • glucose_g (Glucose G) maps to source symbol G; units: mg; evidence: source symbol, component, or units provide a direct public name.
  • glucose_c2 (Glucose C2) maps to source symbol C2; units: mg_per_l; evidence: source symbol, component, or units provide a direct public name.
  • glucose_c3 (Glucose C3) maps to source symbol C3; units: mg_per_l; evidence: source symbol, component, or units provide a direct public name.
  • glucose_c4 (Glucose C4) maps to source symbol C4; units: mU_per_l; evidence: source symbol, component, or units provide a direct public name.
  • glucose_c5 (Glucose C5) maps to source symbol C5; units: mU_per_l; evidence: source symbol, component, or units provide a direct public name.
  • glucose_rg (Glucose Rg) maps to source symbol Rg; units: mg_per_min; evidence: source symbol, component, or units provide a direct public name.

Ambiguous source symbols are intentionally given conservative names such as model_state_*, cell_population_*, or rate_constant_* rather than unsupported biological interpretations.

Visualisations

Visual scope: Glucose, insulin, and regulatory species trajectories; peak glucose/insulin response bars; glycemic recovery Q/A.

The visualisation renders a scientific Q/A table, selected source-variable trajectories, final observable values, and source/runtime evidence. The cards use runtime outputs from the core wrapper and suppress empty data.

Output Visualizations

01-tolic2000-glucose-insulin-lab-physiology-run-answer

02-selected-physiology-trajectories

03-selected-final-observable-values

04-source-and-runtime-evidence

Caveat

This validates source-faithful execution and Biosimulant wiring for glucose-insulin physiology; it does not claim clinical safety or full reproduction of every upstream figure.

Source-faithful physiology lab for Tolic, Mosekilde, Sturis, 2000. Public controls and outputs are mapped to real source symbols for glucose-insulin physiology.

Runtime

Duration0.01
Comms Step0.01
Settle Steps1

Runs

Total0
Completed0
Failed0

Metadata

Packagetolic2000-glucose-insulin-lab
Created2026-05-23
Updated2026-05-23
physiologycellmlphysiomefaithfulvisualisationother

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_glucose_g",
        "label": "Initial Glucose G",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.initial_glucose_g",
        "description": "Initial value for Glucose G. Maps to source symbol `G`. Units: mg. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "mg"
        ]
      },
      {
        "name": "initial_delay_x1",
        "label": "Initial Delay X1",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.initial_delay_x1",
        "description": "Initial value for Delay X1. Maps to source symbol `x1`. Units: min. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "min"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.variable_labels"
      },
      {
        "name": "glucose_g",
        "label": "Glucose G",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.glucose_g",
        "description": "Glucose G. Maps to source symbol `G`. Units: mg. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "glucose_c2",
        "label": "Glucose C2",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.glucose_c2",
        "description": "Glucose C2. Maps to source symbol `C2`. Units: mg_per_l. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "glucose_c3",
        "label": "Glucose C3",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.glucose_c3",
        "description": "Glucose C3. Maps to source symbol `C3`. Units: mg_per_l. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "glucose_c4",
        "label": "Glucose C4",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.glucose_c4",
        "description": "Glucose C4. Maps to source symbol `C4`. Units: mU_per_l. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "glucose_c5",
        "label": "Glucose C5",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.glucose_c5",
        "description": "Glucose C5. Maps to source symbol `C5`. Units: mU_per_l. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "glucose_rg",
        "label": "Glucose Rg",
        "maps_to": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.glucose_rg",
        "description": "Glucose Rg. Maps to source symbol `Rg`. Units: mg_per_min. Naming evidence: source symbol, component, or units provide a direct public name."
      }
    ]
  },
  "title": "Tolic2000 - Glucose Insulin Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model",
      "alias": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model",
      "parameters": {
        "model_path": "data/tolic_mosekilde_sturis_2000.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model_state"
      ],
      "from": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model_summary"
      ],
      "from": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model_trajectory"
      ],
      "from": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model_variable_labels"
      ],
      "from": "physiology_cellml_tolic_mosekilde_sturis_2000_tolicmosekildesturis2000_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Tolic, Mosekilde, Sturis, 2000. Public controls and outputs are mapped to real source symbols for glucose-insulin physiology.",
  "schema_version": "2.0"
}

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