Thiaville2016 - Folate pathway model (PanB overexpression and THF regulation) Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_folate_metabolism_state_1",
        "units": "native SBML value",
        "default": 0.000003315,
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.initial_folate_metabolism_state_1",
        "description": "Initial condition for folate metabolism state 1. Maps to bundled SBML symbol `H2_HMPt`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_folate_metabolism_state_2",
        "units": "native SBML value",
        "default": 0.00001,
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.initial_folate_metabolism_state_2",
        "description": "Initial condition for folate metabolism state 2. Maps to bundled SBML symbol `H2_HMPterinPP`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_para_aminobenzoate",
        "units": "native SBML value",
        "default": 0.00001,
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.initial_para_aminobenzoate",
        "description": "Initial condition for para aminobenzoate. Maps to bundled SBML symbol `p_ABA`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_folate_metabolism_state_4",
        "units": "native SBML value",
        "default": 0.00001,
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.initial_folate_metabolism_state_4",
        "description": "Initial condition for folate metabolism state 4. Maps to bundled SBML symbol `H2_Pteroate`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_dihydrofolate",
        "units": "native SBML value",
        "default": 0.00001,
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.initial_dihydrofolate",
        "description": "Initial condition for dihydrofolate. Maps to bundled SBML symbol `DHF`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      }
    ],
    "outputs": [
      {
        "name": "folate_metabolism_state_1",
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.folate_metabolism_state_1"
      },
      {
        "name": "folate_metabolism_state_2",
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.folate_metabolism_state_2"
      },
      {
        "name": "para_aminobenzoate",
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.para_aminobenzoate"
      },
      {
        "name": "folate_metabolism_state_4",
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.folate_metabolism_state_4"
      },
      {
        "name": "dihydrofolate",
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.dihydrofolate"
      },
      {
        "name": "observable_values",
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.observable_values"
      },
      {
        "name": "run_summary",
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.run_summary"
      },
      {
        "name": "observable_labels",
        "maps_to": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.observable_labels"
      }
    ]
  },
  "title": "Thiaville2016 - Folate pathway model (PanB overexpression and THF regulation) Lab",
  "models": [
    {
      "path": "owned/models/metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model",
      "alias": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model",
      "parameters": {
        "model_path": "data/BIOMD0000000690.xml",
        "integration_step": 0.1
      },
      "provenance": {
        "owned_path": "owned/models/metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model_observable_values"
      ],
      "from": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.observable_values"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model_run_summary"
      ],
      "from": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.run_summary"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model_observable_labels"
      ],
      "from": "metabolism_sbml_thiaville2016_folate_pathway_model_panb_overexpr_biomd0000000690_model.observable_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Henry2016 Folate pathway model with inducedPanB reaction This model is described in the article: Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydrox. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
  "schema_version": "2.0"
}