Arciero2004 - A mathematical model of tumor-immune evasion and siRNA treatment Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_unresolved_tumor_observable_1",
        "label": "Initial Unresolved Tumor Observable 1",
        "units": "native source value",
        "default": 1000,
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.initial_unresolved_tumor_observable_1",
        "description": "Initial Unresolved Tumor Observable 1. Sets the initial value of bundled SBML species `E`."
      },
      {
        "name": "initial_unresolved_tumor_observable_2",
        "label": "Initial Unresolved Tumor Observable 2",
        "units": "native source value",
        "default": 1,
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.initial_unresolved_tumor_observable_2",
        "description": "Initial Unresolved Tumor Observable 2. Sets the initial value of bundled SBML species `T`."
      },
      {
        "name": "initial_unresolved_tumor_observable_3",
        "label": "Initial Unresolved Tumor Observable 3",
        "units": "native source value",
        "default": 1000,
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.initial_unresolved_tumor_observable_3",
        "description": "Initial Unresolved Tumor Observable 3. Sets the initial value of bundled SBML species `I`."
      },
      {
        "name": "initial_unresolved_tumor_observable_4",
        "label": "Initial Unresolved Tumor Observable 4",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.initial_unresolved_tumor_observable_4",
        "description": "Initial Unresolved Tumor Observable 4. Sets the initial value of bundled SBML species `S`."
      },
      {
        "name": "effector_cell_death_rate",
        "label": "Effector Cell Death Rate",
        "units": "native source value",
        "default": 0.03,
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.effector_cell_death_rate",
        "description": "Effector Cell Death Rate. Sets bundled SBML parameter `mu_1`."
      },
      {
        "name": "tumour_growth_rate",
        "label": "Tumour Growth Rate",
        "units": "native source value",
        "default": 0.18,
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.tumour_growth_rate",
        "description": "Tumour Growth Rate. Sets bundled SBML parameter `r`."
      },
      {
        "name": "interleukin_2_decay_rate",
        "label": "Interleukin 2 Decay Rate",
        "units": "native source value",
        "default": 10,
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.interleukin_2_decay_rate",
        "description": "Interleukin 2 Decay Rate. Sets bundled SBML parameter `mu_2`."
      },
      {
        "name": "transforming_growth_factor_b_decay_rate",
        "label": "Transforming Growth Factor B Decay Rate",
        "units": "native source value",
        "default": 10,
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.transforming_growth_factor_b_decay_rate",
        "description": "Transforming Growth Factor B Decay Rate. Sets bundled SBML parameter `mu_3`."
      }
    ],
    "outputs": [
      {
        "name": "unresolved_tumor_observable_1",
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.unresolved_tumor_observable_1"
      },
      {
        "name": "unresolved_tumor_observable_2",
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.unresolved_tumor_observable_2"
      },
      {
        "name": "unresolved_tumor_observable_3",
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.unresolved_tumor_observable_3"
      },
      {
        "name": "unresolved_tumor_observable_4",
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.unresolved_tumor_observable_4"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.species_labels"
      }
    ]
  },
  "title": "Arciero2004 - A mathematical model of tumor-immune evasion and siRNA treatment Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model_state"
      ],
      "from": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model_summary"
      ],
      "from": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model_species_labels"
      ],
      "from": "immunology_sbml_arciero2004_a_mathematical_model_of_tumor_immune_model1907310002_model.species_labels"
    }
  ],
  "package": "arciero2004-a-mathematical-model-of-tumor-immune-evasion",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.1",
  "description": "This is a mathematical model consisting of a system of nonlinear ordinary differential equations describing tumor cells and immune effectors, as well as the immuno-stimulatory and suppressive cytokine. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}