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Ma2005 Digital Response Of P53 To Dna Damage Atm Activation Modul Lab

About lab

Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is “digital” in that it is the number of oscillations rather than the amplitude of p53 that shows dependence on. It can be used to explore systemsbiology ma2005 digital response of p53 dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packagema2005-digital-response-of-p53-to-dna-damage-atm-activation-modu
Created2026-05-17
Updated2026-05-17
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_atm_star",
        "label": "Initial Atm Star",
        "maps_to": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.initial_atm_star",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ATM_star`."
      },
      {
        "name": "initial_atm_d",
        "label": "Initial Atm D",
        "maps_to": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.initial_atm_d",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ATM_D`."
      },
      {
        "name": "initial_model_state_atm",
        "label": "Initial Model State Atm",
        "maps_to": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.initial_model_state_atm",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ATM`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.species_labels"
      },
      {
        "name": "atm_star",
        "maps_to": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.atm_star"
      },
      {
        "name": "atm_d",
        "maps_to": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.atm_d"
      },
      {
        "name": "atm",
        "maps_to": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.atm"
      }
    ]
  },
  "tags": [
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Ma2005 Digital Response Of P53 To Dna Damage Atm Activation Modul Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model",
      "alias": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model_state"
      ],
      "from": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model_summary"
      ],
      "from": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model_species_labels"
      ],
      "from": "systemsbiology_sbml_ma2005_digital_response_of_p53_to_dna_damage_atm_model2005130001_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Recent observations show that the single-cell response of p53 to ionizing radiation (IR) is “digital” in that it is the number of oscillations rather than the amplitude of p53 that shows dependence on. It can be used to explore systemsbiology ma2005 digital response of p53 dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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