About lab
Its a mechanistic model explaining the impact of p53 on apoptosis decision. It can be used to explore systemsbiology zhang2007 mechanism of dna damage dynamics and compare simulation behavior across conditions.
Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagezhang2007-mechanism-of-dna-damage-response-2-lab
Created2026-05-17
Updated2026-05-17
cellcyclesystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation
Manifest
{
"io": {
"inputs": [
{
"name": "initial_dn_adamage",
"label": "Initial Dn Adamage",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.initial_dn_adamage",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `DNAdamage`."
},
{
"name": "initial_p53_total",
"label": "Initial P53 Total",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.initial_p53_total",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `p53_total`."
},
{
"name": "initial_p53_inact",
"label": "Initial P53 Inact",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.initial_p53_inact",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `p53_inact`."
},
{
"name": "initial_p53_act",
"label": "Initial P53 Act",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.initial_p53_act",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `p53_act`."
},
{
"name": "initial_mdm2nuc",
"label": "Initial Mdm2nuc",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.initial_mdm2nuc",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MDM2nuc`."
},
{
"name": "initial_mdm2cyt",
"label": "Initial Mdm2cyt",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.initial_mdm2cyt",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MDM2cyt`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.species_labels"
},
{
"name": "dn_adamage",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.dn_adamage"
},
{
"name": "p53_total",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.p53_total"
},
{
"name": "p53_inact",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.p53_inact"
},
{
"name": "p53_act",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.p53_act"
},
{
"name": "mdm2nuc",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.mdm2nuc"
},
{
"name": "mdm2cyt",
"maps_to": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.mdm2cyt"
}
]
},
"tags": [
"cellcycle",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Zhang2007 Mechanism Of Dna Damage Response 2 Lab",
"models": [
{
"path": "owned/models/systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model",
"alias": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model",
"provenance": {
"owned_path": "owned/models/systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model_state"
],
"from": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model_summary"
],
"from": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model_species_labels"
],
"from": "systemsbiology_sbml_zhang2007_mechanism_of_dna_damage_response_model_biomd0000001009_model.species_labels"
}
],
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"description": "Its a mechanistic model explaining the impact of p53 on apoptosis decision. It can be used to explore systemsbiology zhang2007 mechanism of dna damage dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
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