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Anderson2015 - Qualitative behavior of systems of tumor-CD4+-cytokine interactions with treatments Lab

About lab

This is a mathematical model describing tumor-CD4+-cytokine interactions, with specific emphasis on the role that CD4+ T lymphocytes play in tumor regression. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packageanderson2015-qualitative-behavior-of-systems-of-tumor-cd4-cytoki
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_tumor_cells",
        "label": "Initial Tumor Cells",
        "units": "native source value",
        "default": 0.5,
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.initial_tumor_cells",
        "description": "Initial Tumor Cells. Sets the initial value of bundled SBML species `x_Tumor_Cells`."
      },
      {
        "name": "initial_cd4_t_cells",
        "label": "Initial CD4 T Cells",
        "units": "native source value",
        "default": 0.01,
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.initial_cd4_t_cells",
        "description": "Initial CD4 T Cells. Sets the initial value of bundled SBML species `y_CD4_T_Cells`."
      },
      {
        "name": "initial_cytokine",
        "label": "Initial Cytokine",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.initial_cytokine",
        "description": "Initial Cytokine. Sets the initial value of bundled SBML species `z_Cytokine`."
      },
      {
        "name": "tumor_growth_rate",
        "label": "Tumor Growth Rate",
        "units": "native source value",
        "default": 0.03,
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.tumor_growth_rate",
        "description": "Tumor Growth Rate. Sets bundled SBML parameter `r`."
      },
      {
        "name": "tumor_killing_rate",
        "label": "Tumor Killing Rate",
        "units": "native source value",
        "default": 0.1,
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.tumor_killing_rate",
        "description": "Tumor Killing Rate. Sets bundled SBML parameter `delta`."
      }
    ],
    "outputs": [
      {
        "name": "tumor_cells",
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.tumor_cells"
      },
      {
        "name": "cd4_t_cells",
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.cd4_t_cells"
      },
      {
        "name": "cytokine",
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.cytokine"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.species_labels"
      }
    ]
  },
  "title": "Anderson2015 - Qualitative behavior of systems of tumor-CD4+-cytokine interactions with treatments Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model",
      "alias": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model_state"
      ],
      "from": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model_summary"
      ],
      "from": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model_species_labels"
      ],
      "from": "immunology_sbml_anderson2015_qualitative_behavior_of_systems_of_biomd0000000813_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "This is a mathematical model describing tumor-CD4+-cytokine interactions, with specific emphasis on the role that CD4+ T lymphocytes play in tumor regression. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}

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