Physiome 361 - Arresting Mitotic Oscillator Control Cell Proliferation Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_cell_cycle_state_m",
        "label": "Initial Cell Cycle State M (source M)",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.initial_cell_cycle_state_m",
        "description": "Initial value for Cell Cycle State M (source M). Maps to source symbol `M`. Units: micromolar. Naming evidence: cell-cycle or mitotic context supports a conservative source-state label.",
        "accepted_units": [
          "micromolar"
        ]
      },
      {
        "name": "initial_cell_cycle_state_x",
        "label": "Initial Cell Cycle State X (source X)",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.initial_cell_cycle_state_x",
        "description": "Initial value for Cell Cycle State X (source X). Maps to source symbol `X`. Units: micromolar. Naming evidence: cell-cycle context supports a conservative source-state label.",
        "accepted_units": [
          "micromolar"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.variable_labels"
      },
      {
        "name": "cell_cycle_state_m",
        "label": "Cell Cycle State M (source M)",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.cell_cycle_state_m",
        "description": "Cell Cycle State M (source M). Maps to source symbol `M`. Units: micromolar. Naming evidence: cell-cycle or mitotic context supports a conservative source-state label."
      },
      {
        "name": "cell_cycle_state_x",
        "label": "Cell Cycle State X (source X)",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.cell_cycle_state_x",
        "description": "Cell Cycle State X (source X). Maps to source symbol `X`. Units: micromolar. Naming evidence: cell-cycle context supports a conservative source-state label."
      },
      {
        "name": "cell_cycle_state_k_c",
        "label": "Cell Cycle State K C (source K_c)",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.cell_cycle_state_k_c",
        "description": "Cell Cycle State K C (source K_c). Maps to source symbol `K_c`. Units: micromolar. Naming evidence: cell-cycle context supports a conservative source-state label."
      },
      {
        "name": "c_concentration",
        "label": "C Concentration",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.c_concentration",
        "description": "C Concentration. Maps to source symbol `C`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "rate_constant_k_1",
        "label": "Rate Constant K 1 (source K_1)",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.rate_constant_k_1",
        "description": "Rate Constant K 1 (source K_1). Maps to source symbol `K_1`. Units: per_minute. Naming evidence: units identify a rate constant but not a fuller biological role."
      },
      {
        "name": "rate_constant_k_2",
        "label": "Rate Constant K 2 (source K_2)",
        "maps_to": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.rate_constant_k_2",
        "description": "Rate Constant K 2 (source K_2). Maps to source symbol `K_2`. Units: per_minute. Naming evidence: units identify a rate constant but not a fuller biological role."
      }
    ]
  },
  "title": "Physiome 361 - Arresting Mitotic Oscillator Control Cell Proliferation Lab",
  "models": [
    {
      "path": "owned/models/physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model",
      "alias": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model",
      "parameters": {
        "model_path": "data/goldbeter_guilmot_1995.cellml",
        "integration_step": 0.01
      },
      "provenance": {
        "owned_path": "owned/models/physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model_state"
      ],
      "from": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model_summary"
      ],
      "from": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model_trajectory"
      ],
      "from": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model_variable_labels"
      ],
      "from": "physiology_cellml_arresting_the_mitotic_oscillator_and_the_control_361_model.variable_labels"
    }
  ],
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "description": "Source-faithful physiology lab for Arresting the mitotic oscillator and the control of cell proliferation: insights from a cascade model for cdc2 kinase activation. Public controls and outputs are mapped to real source symbols for oscillatory physiology.",
  "schema_version": "2.0"
}