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Koo2013 - Shear stress induced AKT and eNOS phosphorylation - Model 2 Lab

About lab

Clean Biosimulant lab for systems signaling model: Koo2013 - Shear stress induced AKT and eNOS phosphorylation - Model 2. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.

Runtime

Duration1
Comms Step0.1

Runs

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Completed0
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Metadata

Packagekoo2013-shear-stress-induced-akt-and-enos-phosphorylation-model
Created2026-05-16
Updated2026-05-16
signalingsystemssystems-biologysbmlfaithfulbiomodels_ebipi3k-aktstress-responsevisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_shear_stress",
        "label": "Initial Shear Stress",
        "maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.initial_shear_stress",
        "description": "Initial level of Shear Stress. Maps to SBML symbol `s119`; exposed as a traceable initial-condition perturbation."
      }
    ],
    "outputs": [
      {
        "name": "akt",
        "label": "AKT",
        "maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.akt",
        "description": "AKT. Maps to SBML symbol `s16` and is emitted in native SBML units."
      },
      {
        "name": "p_akt_pi3p",
        "label": "P AKT PI3P",
        "maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.p_akt_pi3p",
        "description": "P AKT PI3P. Maps to SBML symbol `s26` and is emitted in native SBML units."
      },
      {
        "name": "pp_akt_pi3p",
        "label": "Pp AKT PI3P",
        "maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.pp_akt_pi3p",
        "description": "Pp AKT PI3P. Maps to SBML symbol `s27` and is emitted in native SBML units."
      },
      {
        "name": "state",
        "label": "Observable state",
        "maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.species_labels"
      }
    ]
  },
  "tags": [
    "signaling",
    "systems",
    "systems-biology",
    "sbml",
    "faithful",
    "biomodels_ebi",
    "pi3k-akt",
    "stress-response"
  ],
  "title": "Koo2013 - Shear stress induced AKT and eNOS phosphorylation - Model 2 Lab",
  "models": [
    {
      "path": "owned/models/signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model",
      "alias": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model",
      "provenance": {
        "owned_path": "owned/models/signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model_state"
      ],
      "from": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.state"
    },
    {
      "to": [
        "visualisation.signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model_summary"
      ],
      "from": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.summary"
    },
    {
      "to": [
        "visualisation.signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model_species_labels"
      ],
      "from": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Clean Biosimulant lab for systems signaling model: Koo2013 - Shear stress induced AKT and eNOS phosphorylation - Model 2. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
  "schema_version": "2.0"
}

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