Lombardo2018 - Expression of PDL1 in Neuroblastoma Cancer Cell Lab

{
  "io": {
    "inputs": [
      {
        "name": "km_egf_source_parameter",
        "label": "KmEGF source parameter",
        "units": "native SBML value",
        "default": 6086070,
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.km_egf_source_parameter",
        "description": "KmEGF source parameter. Maps to bundled SBML parameter `KmEGF`."
      },
      {
        "name": "kcat_egf_source_parameter",
        "label": "KcatEGF source parameter",
        "units": "native SBML value",
        "default": 694.731,
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.kcat_egf_source_parameter",
        "description": "KcatEGF source parameter. Maps to bundled SBML parameter `KcatEGF`."
      },
      {
        "name": "initial_ngfr",
        "label": "NGFR",
        "units": "native SBML value",
        "default": 14737,
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.initial_ngfr",
        "description": "Initial NGFR. Sets the initial value of bundled SBML symbol `NGFR`."
      },
      {
        "name": "initial_pip3",
        "label": "PIP3",
        "units": "native SBML value",
        "default": 100000,
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.initial_pip3",
        "description": "Initial PIP3. Sets the initial value of bundled SBML symbol `PIP3`."
      },
      {
        "name": "initial_egfr_free",
        "label": "EGFR free",
        "units": "native SBML value",
        "default": 618,
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.initial_egfr_free",
        "description": "Initial EGFR free. Sets the initial value of bundled SBML symbol `EGFR_f`."
      },
      {
        "name": "initial_sos_inactive",
        "label": "SOS inactive",
        "units": "native SBML value",
        "default": 9456,
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.initial_sos_inactive",
        "description": "Initial SOS inactive. Sets the initial value of bundled SBML symbol `SOS_inactive`."
      }
    ],
    "outputs": [
      {
        "name": "ngfr",
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.ngfr",
        "description": "NGFR observable. Maps to SBML symbol `NGFR`."
      },
      {
        "name": "pip3",
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.pip3",
        "description": "PIP3 observable. Maps to SBML symbol `PIP3`."
      },
      {
        "name": "egfr_free",
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.egfr_free",
        "description": "EGFR free observable. Maps to SBML symbol `EGFR_f`."
      },
      {
        "name": "sos_inactive",
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.sos_inactive",
        "description": "SOS inactive observable. Maps to SBML symbol `SOS_inactive`."
      },
      {
        "name": "p90_rsk_inactive",
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.p90_rsk_inactive",
        "description": "P90Rsk inactive observable. Maps to SBML symbol `P90Rsk_inactive`."
      },
      {
        "name": "ras_inactive",
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.ras_inactive",
        "description": "RAS inactive observable. Maps to SBML symbol `RAS_inactive`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Lombardo2018 - Expression of PDL1 in Neuroblastoma Cancer Cell Lab",
  "models": [
    {
      "path": "owned/models/oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model",
      "alias": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model",
      "provenance": {
        "owned_path": "owned/models/oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model_state"
      ],
      "from": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model_summary"
      ],
      "from": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model_species_labels"
      ],
      "from": "oncology_sbml_lombardo2018_expression_of_pdl1_in_neuroblastoma_model1812070002_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 0.00575,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "The model reproduces the time profiles of PDL1 in a Neuroblastoma Cancer Cell, considering the activating mutation of ALK: ALKF1174L. We simulate the impact of two different therapy: Crizotinib and Ge.",
  "schema_version": "2.0"
}