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Smith2011 - Three Stage Innate Immune Response to a Pneumococcal Lung Infection Lab

About lab

Pneumococcal pneumonia is a leading cause of death and a major source of human morbidity. The initial immune response plays a central role in determining the course and outcome of pneumococcal disease.

Runtime

Duration10
Comms Step1

Runs

Total0
Completed0
Failed0

Metadata

Packagesmith2011-three-stage-innate-immune-response-to-a-pneumococcal-l
Created2026-05-15
Updated2026-05-15
immunologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_epithelial_cells_with_bacteria_attached_ea",
        "label": "Initial Epithelial Cells With Bacteria Attached Ea",
        "units": "substance",
        "default": 0,
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.initial_epithelial_cells_with_bacteria_attached_ea",
        "description": "Initial Epithelial Cells With Bacteria Attached Ea. Sets the initial value of bundled SBML species `Epithelial_cells_with_bacteria_attached__Ea`."
      },
      {
        "name": "initial_pneumococci_p",
        "label": "Initial Pneumococci P",
        "units": "substance",
        "default": 100000,
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.initial_pneumococci_p",
        "description": "Initial Pneumococci P. Sets the initial value of bundled SBML species `Pneumococci___P`."
      },
      {
        "name": "initial_susceptible_epithelial_cells_eu",
        "label": "Initial Susceptible Epithelial Cells Eu",
        "units": "substance",
        "default": 100000000,
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.initial_susceptible_epithelial_cells_eu",
        "description": "Initial Susceptible Epithelial Cells Eu. Sets the initial value of bundled SBML species `Susceptible_epithelial_cells__EU`."
      },
      {
        "name": "initial_proinflammatory_cytokine_c",
        "label": "Initial Proinflammatory Cytokine C",
        "units": "substance",
        "default": 0,
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.initial_proinflammatory_cytokine_c",
        "description": "Initial Proinflammatory Cytokine C. Sets the initial value of bundled SBML species `proinflammatory_cytokine__C`."
      },
      {
        "name": "initial_neutrophils_n",
        "label": "Initial Neutrophils N",
        "units": "substance",
        "default": 0,
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.initial_neutrophils_n",
        "description": "Initial Neutrophils N. Sets the initial value of bundled SBML species `Neutrophils__N`."
      }
    ],
    "outputs": [
      {
        "name": "epithelial_cells_with_bacteria_attached_ea",
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.epithelial_cells_with_bacteria_attached_ea"
      },
      {
        "name": "pneumococci_p",
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.pneumococci_p"
      },
      {
        "name": "susceptible_epithelial_cells_eu",
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.susceptible_epithelial_cells_eu"
      },
      {
        "name": "proinflammatory_cytokine_c",
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.proinflammatory_cytokine_c"
      },
      {
        "name": "neutrophils_n",
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.neutrophils_n"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.species_labels"
      }
    ]
  },
  "title": "Smith2011 - Three Stage Innate Immune Response to a Pneumococcal Lung Infection Lab",
  "models": [
    {
      "path": "owned/models/immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model",
      "alias": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model",
      "provenance": {
        "owned_path": "owned/models/immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model_state"
      ],
      "from": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model_summary"
      ],
      "from": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model_species_labels"
      ],
      "from": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "description": "Pneumococcal pneumonia is a leading cause of death and a major source of human morbidity. The initial immune response plays a central role in determining the course and outcome of pneumococcal disease.",
  "schema_version": "2.0"
}

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