About lab
Collier1996 - Delta Notch intercellular signalling and lateral inhibition
This Biosimulant lab wraps Collier1996 - Delta Notch intercellular signalling and lateral inhibition as a runnable signaling model with a companion visualization module.
Clean Biosimulant lab for developmental and growth-control signaling. It can be used to explore second-messenger and pathway-signaling dynamics and compare scenario outcomes across configurations.
What You'll See
The lab asks: How does Collier1996 - Delta Notch intercellular signalling and lateral inhibition shift developmental or growth-control pathway states? It runs for 1.0 time units with a communication step of 0.1. The run uses the model defaults declared by the curated SBML wrapper. The generated visualizations focus on Delta1, Delta2, Notch1, and Notch2, combining trajectory, endpoint-comparison, and summary-table views from one completed dark-mode run.
In this captured run, DELTA1 moved from 1.0000 to 0.4125 across 1.0 simulation windows.
Output Visualizations
Summary table for Collier1996 - Delta Notch intercellular signalling and lateral inhibition, reporting the scientific question, observed answer, dominant module, and caveat.
Trajectories of DELTA1, DELTA2, NOTCH1, and NOTCH2 across the 1.0 simulation. In this run DELTA1 fell from 1.0000 to 0.4125 — the largest movements among the focused observables.
Largest-excursion ranking of the focused observables — the absolute movement magnitude during the run. Top 3: NOTCH1 = 0.9819, NOTCH2 = 0.9781, DELTA1 = 0.4125, with 1 more observable below.
Model Context
- Core model:
models/core - Visualization model:
models/visualisation - Standard:
other - Upstream source:
biomodels_ebi:BIOMD0000001047 - License:
CC0 - Visual scope: growth-control pathway signaling
- Caveat: Values are native SBML quantities; equations, parameters, units, and initial values remain in the bundled source file.
Inputs
| Input | Maps To | Default | Notes |
|---|---|---|---|
| Initial Notch1 | signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.initial_notch1 | Initial level of Notch1. Maps to SBML symbol notch1; exposed as a traceable initial-condition perturbation. | |
| Initial Notch2 | signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.initial_notch2 | Initial level of Notch2. Maps to SBML symbol notch2; exposed as a traceable initial-condition perturbation. |
Outputs
| Output | Maps To | Role |
|---|---|---|
delta1 | signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.delta1 | Delta1. |
delta2 | signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.delta2 | Delta2. |
notch1 | signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.notch1 | Notch1. |
state | signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.state | Available to the visualization model and downstream workflows. |
summary | signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.summary | Available to the visualization model and downstream workflows. |
species_labels | signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.species_labels | Available to the visualization model and downstream workflows. |
Runtime
- Duration:
1.0 - Communication step:
0.1
Running Locally
biosimulant labs serve .
Clean Biosimulant lab for developmental and growth-control signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.
Runtime
Runs
Metadata
Manifest
{
"io": {
"inputs": [
{
"name": "initial_notch1",
"label": "Initial Notch1",
"maps_to": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.initial_notch1",
"description": "Initial level of Notch1. Maps to SBML symbol `notch1`; exposed as a traceable initial-condition perturbation."
},
{
"name": "initial_notch2",
"label": "Initial Notch2",
"maps_to": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.initial_notch2",
"description": "Initial level of Notch2. Maps to SBML symbol `notch2`; exposed as a traceable initial-condition perturbation."
}
],
"outputs": [
{
"name": "delta1",
"label": "Delta1",
"maps_to": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.delta1",
"description": "Delta1. Maps to SBML symbol `delta1` and is emitted in native SBML units."
},
{
"name": "delta2",
"label": "Delta2",
"maps_to": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.delta2",
"description": "Delta2. Maps to SBML symbol `delta2` and is emitted in native SBML units."
},
{
"name": "notch1",
"label": "Notch1",
"maps_to": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.notch1",
"description": "Notch1. Maps to SBML symbol `notch1` and is emitted in native SBML units."
},
{
"name": "state",
"label": "Observable state",
"maps_to": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.state"
},
{
"name": "summary",
"label": "Simulation summary",
"maps_to": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.summary"
},
{
"name": "species_labels",
"label": "Observable labels",
"maps_to": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.species_labels"
}
]
},
"tags": [
"signaling",
"systems",
"systems-biology",
"sbml",
"faithful",
"biomodels_ebi",
"notch"
],
"title": "Collier1996 - Delta Notch intercellular signalling and lateral inhibition Lab",
"models": [
{
"path": "owned/models/signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model",
"alias": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model",
"provenance": {
"owned_path": "owned/models/signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model_state"
],
"from": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.state"
},
{
"to": [
"visualisation.signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model_summary"
],
"from": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.summary"
},
{
"to": [
"visualisation.signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model_species_labels"
],
"from": "signaling_sbml_collier1996_delta_notch_intercellular_signalling_biomd0000001047_model.species_labels"
}
],
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"description": "Clean Biosimulant lab for developmental and growth-control signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
"schema_version": "2.0"
}Sign in to start your own run. Public-lab history stays visible here.
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