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Proctor2016 - Circadian rhythm of PTH and the dynamics of signaling molecules on bone remodeling Lab

About lab

Clean Biosimulant lab for circadian regulatory signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packageproctor2016-circadian-rhythm-of-pth-and-the-dynamics-of-signalin
Created2026-05-16
Updated2026-05-16
signalingsystemssystems-biologysbmlfaithfulbiomodels_ebicircadianphysiologyvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_kact_tgf_beta_level",
        "label": "Kact TGF-beta",
        "maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.initial_kact_tgf_beta_level",
        "description": "Kact TGF-beta source parameter. Maps to SBML symbol `kactTgfb` and preserves the bundled default."
      },
      {
        "name": "initial_sink_species",
        "label": "Initial sink species",
        "maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.initial_sink_species",
        "description": "Initial level of sink species. Maps to SBML symbol `Sink`; exposed as a traceable initial-condition perturbation."
      },
      {
        "name": "initial_source",
        "label": "Initial Source",
        "maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.initial_source",
        "description": "Initial level of Source. Maps to SBML symbol `Source`; exposed as a traceable initial-condition perturbation."
      }
    ],
    "outputs": [
      {
        "name": "source_defined_bone_state",
        "label": "Source Defined BONE State",
        "maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.source_defined_bone_state",
        "description": "Source Defined BONE State. Maps to SBML symbol `Bone` and is emitted in native SBML units."
      },
      {
        "name": "source_defined_hsc_state",
        "label": "Source Defined HSC State",
        "maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.source_defined_hsc_state",
        "description": "Source Defined HSC State. Maps to SBML symbol `HSC` and is emitted in native SBML units."
      },
      {
        "name": "source_defined_ob_m_state",
        "label": "Source Defined OB M State",
        "maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.source_defined_ob_m_state",
        "description": "Source Defined OB M State. Maps to SBML symbol `Ob_m` and is emitted in native SBML units."
      },
      {
        "name": "state",
        "label": "Observable state",
        "maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.species_labels"
      }
    ]
  },
  "tags": [
    "signaling",
    "systems",
    "systems-biology",
    "sbml",
    "faithful",
    "biomodels_ebi",
    "circadian",
    "physiology"
  ],
  "title": "Proctor2016 - Circadian rhythm of PTH and the dynamics of signaling molecules on bone remodeling Lab",
  "models": [
    {
      "path": "owned/models/signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model",
      "alias": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model",
      "provenance": {
        "owned_path": "owned/models/signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model_state"
      ],
      "from": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.state"
    },
    {
      "to": [
        "visualisation.signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model_summary"
      ],
      "from": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.summary"
    },
    {
      "to": [
        "visualisation.signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model_species_labels"
      ],
      "from": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "Clean Biosimulant lab for circadian regulatory signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
  "schema_version": "2.0"
}

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