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Schmierer2008 Smad Tgfb Lab

About lab

This sbml file describes the RECI model from: 'Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system' by Bernhard Schmierer, Alexander L. It can be used to explore systemsbiology schmierer 2008 smad tgfb BioModels0000000173 dynamics and compare simulation behavior across conditions.

Runtime

Duration1
Comms Step0.1

Runs

Total0
Completed0
Failed0

Metadata

Packageschmierer2008-smad-tgfb-lab
Created2026-05-17
Updated2026-05-17
signalingsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "initial_smad2_c",
        "label": "Initial Smad2 C",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_smad2_c",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `S2_c`."
      },
      {
        "name": "initial_gfp_smad2_c",
        "label": "Initial Gfp Smad2 C",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_gfp_smad2_c",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `G_c`."
      },
      {
        "name": "initial_smad4_c",
        "label": "Initial Smad4 C",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_smad4_c",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `S4_c`."
      },
      {
        "name": "initial_smad4_n",
        "label": "Initial Smad4 N",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_smad4_n",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `S4_n`."
      },
      {
        "name": "initial_smad2_n",
        "label": "Initial Smad2 N",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_smad2_n",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `S2_n`."
      },
      {
        "name": "initial_gfp_smad2_n",
        "label": "Initial Gfp Smad2 N",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_gfp_smad2_n",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `G_n`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.species_labels"
      },
      {
        "name": "smad2_c",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.smad2_c"
      },
      {
        "name": "gfp_smad2_c",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.gfp_smad2_c"
      },
      {
        "name": "smad4_c",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.smad4_c"
      },
      {
        "name": "smad4_n",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.smad4_n"
      },
      {
        "name": "smad2_n",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.smad2_n"
      },
      {
        "name": "gfp_smad2_n",
        "maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.gfp_smad2_n"
      }
    ]
  },
  "tags": [
    "signaling",
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Schmierer2008 Smad Tgfb Lab",
  "models": [
    {
      "path": "owned/models/systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model",
      "alias": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model",
      "provenance": {
        "owned_path": "owned/models/systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model"
      }
    },
    {
      "path": "owned/models/visualisation",
      "alias": "visualisation",
      "provenance": {
        "owned_path": "owned/models/visualisation"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model_state"
      ],
      "from": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model_summary"
      ],
      "from": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model_species_labels"
      ],
      "from": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "description": "This sbml file describes the RECI model from: 'Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system' by Bernhard Schmierer, Alexander L. It can be used to explore systemsbiology schmierer 2008 smad tgfb BioModels0000000173 dynamics and compare simulation behavior across conditions.",
  "schema_version": "2.0"
}

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