About lab
This model is taken from <a href = 'http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15548210&query_hl=1&itool=pubmed_docsum'>. It can be used to explore systemsbiology ajay bhalla 2004 feedback tuning dynamics and compare simulation behavior across conditions.
Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagebhalla2004-ajay-feedback-tuning-lab
Created2026-05-17
Updated2026-05-17
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisation
Manifest
{
"io": {
"inputs": [
{
"name": "initial_egfr_slash_internal_l_dot_egfr",
"label": "Initial EGFR Slash Internal L Dot EGFR",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.initial_egfr_slash_internal_l_dot_egfr",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `EGFR_slash_Internal_L_dot_EGFR`."
},
{
"name": "initial_ac_slash_atp",
"label": "Initial Ac Slash ATP",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.initial_ac_slash_atp",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `AC_slash_ATP`."
},
{
"name": "initial_mapk_slash_mapk",
"label": "Initial MAPK Slash MAPK",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.initial_mapk_slash_mapk",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MAPK_slash_MAPK`."
},
{
"name": "initial_ras_slash_gdp_minus_ras",
"label": "Initial RAS Slash Gdp Minus RAS",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.initial_ras_slash_gdp_minus_ras",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Ras_slash_GDP_minus_Ras`."
},
{
"name": "initial_mapk_slash_mapkk",
"label": "Initial MAPK Slash Mapkk",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.initial_mapk_slash_mapkk",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MAPK_slash_MAPKK`."
},
{
"name": "initial_mapk_slash_craf_minus_1",
"label": "Initial MAPK Slash Craf Minus 1",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.initial_mapk_slash_craf_minus_1",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MAPK_slash_craf_minus_1`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.species_labels"
},
{
"name": "egfr_slash_internal_l_dot_egfr",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.egfr_slash_internal_l_dot_egfr"
},
{
"name": "ac_slash_atp",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.ac_slash_atp"
},
{
"name": "mapk_slash_mapk",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.mapk_slash_mapk"
},
{
"name": "ras_slash_gdp_minus_ras",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.ras_slash_gdp_minus_ras"
},
{
"name": "mapk_slash_mapkk",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.mapk_slash_mapkk"
},
{
"name": "mapk_slash_craf_minus_1",
"maps_to": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.mapk_slash_craf_minus_1"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Bhalla2004 Ajay Feedback Tuning Lab",
"models": [
{
"path": "owned/models/systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model",
"alias": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model",
"provenance": {
"owned_path": "owned/models/systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model"
}
},
{
"path": "owned/models/visualisation",
"alias": "visualisation",
"provenance": {
"owned_path": "owned/models/visualisation"
}
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model_state"
],
"from": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model_summary"
],
"from": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model_species_labels"
],
"from": "systemsbiology_sbml_ajay_bhalla_2004_feedback_tuning_model9089914876_model.species_labels"
}
],
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"description": "This model is taken from <a href = 'http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15548210&query_hl=1&itool=pubmed_docsum'>. It can be used to explore systemsbiology ajay bhalla 2004 feedback tuning dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
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