Cooling2007 Ip3 Transients Myocyte Lab

{
  "io": {
    "inputs": [
      {
        "name": "integration_step",
        "maps_to": "cooling2007_ip3_transients_myocyte_core.integration_step"
      },
      {
        "name": "parameter_overrides",
        "maps_to": "cooling2007_ip3_transients_myocyte_core.parameter_overrides"
      },
      {
        "name": "initial_conditions",
        "maps_to": "cooling2007_ip3_transients_myocyte_core.initial_conditions"
      }
    ],
    "outputs": [
      {
        "name": "scenario_metadata",
        "maps_to": "cooling2007_ip3_transients_myocyte_scenario.scenario_metadata"
      },
      {
        "name": "state",
        "maps_to": "cooling2007_ip3_transients_myocyte_core.state"
      },
      {
        "name": "run_summary",
        "maps_to": "cooling2007_ip3_transients_myocyte_viz.run_summary"
      }
    ]
  },
  "title": "Cooling2007 Ip3 Transients Myocyte Lab",
  "models": [
    {
      "path": "owned/models/cooling2007_ip3_transients_myocyte_scenario",
      "alias": "cooling2007_ip3_transients_myocyte_scenario",
      "parameters": {
        "schedule": {
          "calcium_initial": {
            "unit": "dimensionless",
            "label": "calcium initial",
            "active": true,
            "baseline": 0.1,
            "recovery": 0.1,
            "challenge": 0.2,
            "description": "Scenario-controlled calcium initial value."
          },
          "receptor_initial": {
            "unit": "dimensionless",
            "label": "receptor initial",
            "active": false,
            "baseline": 13.9,
            "recovery": 13.9,
            "challenge": 13.9,
            "description": "Scenario-controlled receptor initial value."
          },
          "inositol_trisphosphate_initial": {
            "unit": "dimensionless",
            "label": "inositol trisphosphate initial",
            "active": false,
            "baseline": 0.015,
            "recovery": 0.015,
            "challenge": 0.015,
            "description": "Scenario-controlled inositol trisphosphate initial value."
          }
        },
        "scenario_name": "Calcium activation challenge",
        "baseline_until": 0.25,
        "challenge_until": 0.75,
        "scenario_description": "Baseline is followed by a calcium initial challenge and recovery period."
      },
      "provenance": {
        "owned_path": "owned/models/cooling2007_ip3_transients_myocyte_scenario"
      }
    },
    {
      "path": "owned/models/cooling2007_ip3_transients_myocyte_core",
      "alias": "cooling2007_ip3_transients_myocyte_core",
      "parameters": {
        "model_path": "data/BIOMD0000000400.xml",
        "integration_step": 0.001
      },
      "provenance": {
        "owned_path": "owned/models/cooling2007_ip3_transients_myocyte_core"
      }
    },
    {
      "path": "owned/models/cooling2007_ip3_transients_myocyte_viz",
      "alias": "cooling2007_ip3_transients_myocyte_viz",
      "parameters": {
        "lab_title": "Cooling2007 Ip3 Transients Myocyte",
        "lab_question": "Does inositol trisphosphate stimulation create a calcium transient?",
        "integration_step": 0.001
      },
      "provenance": {
        "owned_path": "owned/models/cooling2007_ip3_transients_myocyte_viz"
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "cooling2007_ip3_transients_myocyte_core.inositol_trisphosphate_initial"
      ],
      "from": "cooling2007_ip3_transients_myocyte_scenario.inositol_trisphosphate_initial"
    },
    {
      "to": [
        "cooling2007_ip3_transients_myocyte_core.calcium_initial"
      ],
      "from": "cooling2007_ip3_transients_myocyte_scenario.calcium_initial"
    },
    {
      "to": [
        "cooling2007_ip3_transients_myocyte_core.receptor_initial"
      ],
      "from": "cooling2007_ip3_transients_myocyte_scenario.receptor_initial"
    },
    {
      "to": [
        "cooling2007_ip3_transients_myocyte_viz.scenario_metadata"
      ],
      "from": "cooling2007_ip3_transients_myocyte_scenario.scenario_metadata"
    },
    {
      "to": [
        "cooling2007_ip3_transients_myocyte_viz.state"
      ],
      "from": "cooling2007_ip3_transients_myocyte_core.state"
    },
    {
      "to": [
        "cooling2007_ip3_transients_myocyte_viz.species_labels"
      ],
      "from": "cooling2007_ip3_transients_myocyte_core.species_labels"
    }
  ],
  "runtime": {
    "duration": 1,
    "initial_inputs": {
      "cooling2007_ip3_transients_myocyte_core": {
        "integration_step": 0.001,
        "initial_conditions": {
          "payload": {}
        },
        "parameter_overrides": {
          "payload": {}
        }
      }
    },
    "communication_step": 0.001
  },
  "description": "Two-model lab for Cooling2007 Ip3 Transients Myocyte: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Modeling hypertrophic IP3 transients in the cardiac myocyte. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
  "schema_version": "2.0"
}